지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 373 - 387 (15page)
이용수
초록· 키워드
오류제보하기
Objectives: The purpose of this study was to introduce our three experiments on bone morphogenetic protein (BMP) and its carriers performed us-ing the critical sized segmental defect (CSD) model in rat fibula and to investigate development of animal models and carriers for more effective bone regeneration.Materials and Methods: For the experiments, 14, 16, and 24 rats with CSDs on both fibulae were used in Experiments 1, 2, and 3, respectively. BMP-2 with absorbable collagen sponge (ACS) (Experiments 1 and 2), autoclaved autogenous bone (AAB) and fibrin glue (FG) (Experiment 3), and xenogenic bone (Experiment 2) were used in the experimental groups. Radiographic and histomorphological evaluations were performed during the follow-up period of each experiment.Results: Significant new bone formation was commonly observed in all experimental groups using BMP-2 compared to control and xenograft (porcine bone) groups. Although there was some difference based on BMP carrier, regenerated bone volume was typically reduced by remodeling after initially forming excessive bone.Conclusion: BMP-2 demonstrates excellent ability for bone regeneration because of its osteoinductivity, but efficacy can be significantly different depending on its delivery system. ACS and FG showed relatively good bone regeneration capacity, satisfying the essential conditions of localization and release-control when used as BMP carriers. AAB could not provide release-control as a BMP carrier, but its space-maintenance role was remark-able. Carriers and scaffolds that can provide sufficient support to the BMP/carrier complex are necessary for large bone defects, and AAB is thought to be able to act as an effective scaffold. The CSD model of rat fibula is simple and useful for initial estimate of bone regeneration by agents including BMPs.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Boyne PJ / 1997 / A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation / Int J Periodontics Restorative Dent 17 : 11 ~ 25
Boyne PJ / 1998 / Osseous reconstruction of the maxilla and the mandible:surgical techniques using titanium mesh and bone mineral / Implant Dentistry 7 : 378 ~ 379
Dickinson BP / 2008 / Reduced morbidity and improved healing with bone morphogenic protein-2 in older patients with alveolar cleft defects / Plast Reconstr Surg 121 : 209 ~ 2
Fallucco MA / 2009 / Primary reconstruction of alveolar clefts using recombinant human bone morphogenic protein-2: clinical and radiographic outcomes / J Craniofac Surg 20 (S
Haidar ZS / 2009 / Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A:current challenges in BMP delivery / Biotechnol Lett 31 : 181
Boyne PJ / 1998 / Osseous reconstruction of the maxilla and the mandible:surgical techniques using titanium mesh and bone mineral / Implant Dentistry 7 : 378 ~ 379
Dickinson BP / 2008 / Reduced morbidity and improved healing with bone morphogenic protein-2 in older patients with alveolar cleft defects / Plast Reconstr Surg 121 : 209 ~ 2
Fallucco MA / 2009 / Primary reconstruction of alveolar clefts using recombinant human bone morphogenic protein-2: clinical and radiographic outcomes / J Craniofac Surg 20 (S
Haidar ZS / 2009 / Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A:current challenges in BMP delivery / Biotechnol Lett 31 : 181
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Biosilicated collagen/β-tricalcium phosphate composites as a BMP-2-delivering bone-graft substitute for accelerated craniofacial bone regeneration
생체재료학회지
2021 .01
-
Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus
Journal of Periodontal & Implant Science
2016 .01
-
Titanium Mesh for Bone Augmentation in Oral Implant Surgery
대한구강악안면임플란트학회지
2021 .12
-
Three-dimensional printed polylactic acid scaffold integrated with BMP-2 laden hydrogel for precise bone regeneration
생체재료학회지
2021 .12
-
Pre-clinical test platform for the evaluation of bone scaffolds using several animal models in DGMIF-LAC
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Comparison of demineralized bone matrix and hydroxyapatite as carriers of Escherichia coli recombinant human BMP-2
생체재료학회지
2021 .09
-
Bone defect model in animals for evaluation of bone grafts
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Effects of micro-porosity and local BMP-2 administration on bioresorption of β-TCP and new bone formation
생체재료학회지
2019 .01
-
Identification of differentially expressed proteins related with bone regeneration by tooth extraction
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Evaluation of bone regeneration in an osteoporotic rat model
한국실험동물학회 학술발표대회 논문집
2025 .02
-
성공적인 골재생유도술을 위한 고려사항
대한치과의사협회지
2021 .03
-
골 대체물 및 골 치유 촉진에 대한 발전
대한골절학회지
2017 .01
-
Regenerative capacity of augmented bone in rat calvarial guided bone augmentation model
Journal of Periodontal & Implant Science
2017 .01
-
Vertical Ridge Augmentation with Mandibular Ramus Block Bone for Implant Surgery
대한구강악안면임플란트학회지
2021 .01
-
Biomineralization of bone tissue: calcium phosphate-based inorganics in collagen fibrillar organic matrices
생체재료학회지
2022 .09
-
Effects of Escherichia Coli-derived Recombinant Human Bone Morphogenetic Protein-2 Loaded Porous Hydroxyaptite-based Ceramics on Calvarial Defect in Rabbits
대한골대사학회지
2017 .01
-
New types of guided bone regeneration membrane in alveolar bone defect of beagle dog
한국실험동물학회 학술발표대회 논문집
2022 .07
-
골형성유도단백질(rhBMP-2)을 이용한 치조골 결손부의 골이식술
대한치과의사협회지
2015 .01
-
Bone modeling, remodeling, and skeletal health in children and adolescents: mineral accrual, assessment and treatment
Annals of Pediatirc Endocrinology & Metabolism
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0