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논문 기본 정보

자료유형
학술저널
저자정보
Yuan Zhe Jin (Seoul National University) Guang-Bin Zheng (Taizhou Hospial of Zhejiang Province China) 이재협 (서울특별시보라매병원) Shi-Huan Han (Seoul National University)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제25권 제3호
발행연도
2021.9
수록면
314 - 320 (7page)
DOI
https://doi.org/10.1186/s40824-021-00225-7

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Background: Autograft has been widely used in various orthopedic and dental surgery for its superior osteogenicity, osteoinductivity and osteoconductivity. But the available volume of the autograft is limited and the efficacy of it is highly affected by the condition of the patients. Therefore, growth factors such as Escherichia coli bone morphogenetic protein-2 (ErhBMP-2) has been widely used in some countries and regions with various carriers that could affect the effects of the growth factors. Demineralized bone matrix (DBM) has been widely used as a bone graft substitute and growth factor carrier, but its effect as a carrier of ErhBMP-2 was less investigated. Materials and methods: Rat calvaria defect model was used in this study. We implanted ErhBMP-2 with DBM or hydroxyapatite (HA) as a carrier in 8mm calvaria defect and compared their bone regeneration effect in 4th week and 8th week after implantation with micro-CT and histology. The data was analyzed with one-way ANOVA method with Bonferroni post-hoc analysis. Result: The group with DBM as the carrier showed significantly higher bone volume and bone thickness than the groups with HA as the carrier in both weeks. And the histology sections showed less adipose tissue formed in the groups with DBM as the carrier. Conclusion: DBM could be a better carrier for ErhBMP-2 than HA.

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