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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제38권 제7호
- 발행연도
- 2016.7
- 수록면
- 1 - 9 (9page)
- DOI
- 10.1186/s40902-016-0073-1
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초록· 키워드
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Background: The objective of this study was to place bone graft materials in cranial defects in a rabbit model and compare their bone regenerating ability according to the size and density of demineralized dentin matrix (DDM).
Methods: We selected nine healthy male rabbits that were raised under the same conditions and that weighed about 3 kg. Two circular defects 8 mm in diameter were created in each side of the cranium. The defects were grafted with DDM using four different particle sizes and densities: 0.1 mL of 0.25- to 1.0-mm particles (group 1); 0.
2 mL of 0.25- to 1.0-mm particles (group 2); 0.1 mL of 1.0- to 2.0-mm particles (group 3); and 0.2 mL of 1.0- to 2.
0-mm particles (group 4). After 2, 4, and 8 weeks, the rabbits were sacrificed, and bone samples were evaluated by means of histologic, histomorphometric, and quantitative RT-PCR analysis.
Results: In group 1, osteoblast activity and bone formation were greater than in the other three groups on histological examination. In groups 2, 3, and 4, dense connective tissue was seen around original bone even after 8 weeks. Histomorphometric analysis of representative sections in group 1 showed a higher rate of new bone formation, but the difference from the other groups was not statistically significant. RT-PCR analysis indicated a correlation between bone formation and protein (osteonectin and osteopontin) expression.
Conclusions: DDM with a space between particles of 200 μm was effective in bone formation, suggesting that materials with a small particle size could reasonably be used for bone grafting.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Boyne PJ / 1973 / Induction of bone repair by various bone grafting materials, hard tissue growth, repair and remineralization / Ciba Found Symp 11:121~128
Masters DH / 1988 / Implants, bone and bone substitutes / Calif Dent Asso J 16:56~65
Jarcho M / 1981 / Calcium phosphate ceramics as hard tissue prosthetics / Clin Orthop 157:259~278
Arrington ED / 1996 / Complications of iliac crest bone graft harvesting / Clin Orthop Relat Res 329:300~309
Goulet JA / 1997 / Autogenous iliac crest bone graft: complications and functional assessment / Clin Orthop Relat Res 339:76~81
Masters DH / 1988 / Implants, bone and bone substitutes / Calif Dent Asso J 16:56~65
Jarcho M / 1981 / Calcium phosphate ceramics as hard tissue prosthetics / Clin Orthop 157:259~278
Arrington ED / 1996 / Complications of iliac crest bone graft harvesting / Clin Orthop Relat Res 329:300~309
Goulet JA / 1997 / Autogenous iliac crest bone graft: complications and functional assessment / Clin Orthop Relat Res 339:76~81
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