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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 90 - 98 (9page)
이용수
초록· 키워드
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Objectives: The aim of this study was to compare the osteogenic effects of demineralized dentin matrix (DDM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) in rabbit calvarial defects with DDM and anorganic bovine bone (ABB) combined with rhBMP-2.Materials and Methods: Four round defects with 8-mm diameters were created in each rabbit calvaria. Each defect was treated with one of the fol-lowing: 1) DDM, 2) ABB/rhBMP-2, or 3) DDM/rhBMP-2. The rhBMP-2 was combined with DDM and ABB according to a stepwise dry and dip ly-ophilizing protocol. Histological and microcomputed tomography (µCT) analyses were performed to measure the amount of bone formation and bone volume after 2- and 8-week healing intervals.Results: Upon histological observation at two weeks, the DDM and ABB/rhBMP-2 groups showed osteoconductive bone formation, while the DDM/rhBMP-2 group showed osteoconductive and osteoinductive bone formation. New bone formation was higher in DDM/rhBMP-2, DDM and ABB decreasing order. The amounts of bone formation were very similar at two weeks; however, at eight weeks, the DDM/rhBMP-2 group showed a two-fold greater amount of bone formation compared to the DDM and ABB/rhBMP-2 groups. The µCT analysis showed markedly increased bone volume in the DDM/rhBMP-2 group at eight weeks compared with that of the DDM group. Notably, there was a slight decrease in bone volume in the ABB/rhBMP-2 group at eight weeks. There were no significant differences among the DDM, ABB/rhBMP-2, and DDM/rhBMP-2 groups at two or eight weeks.Conclusion: Within the limitations of this study, DDM appears to be a suitable carrier for rhBMP-2 in orthotopic sites.
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참고문헌 (22)
참고문헌 신청
Govender S / 2002 / Recombinant human bone morphogenetic protein-2for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients / J Bone Joint Surg Am 84:2123~2134
Burkus JK / 2003 / Is INFUSE bone graft superior to autograft bone? An integrated analysis of clinical trials using the LT-Cage lumbar tapered fusion device / J Spinal Disord Tech 16:113~122
Ripamonti U / 1994 / Periodontal regeneration: potential role of bone morphogenetic proteins / J Periodontal Res 29:225~235
Asahina I / 2014 / Bone morphogenetic proteins: their history and characteristics / J Hard Tissue Biol 23:283~286
Gauthier O / 1998 / Biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth / Biomaterials 19:133~139
Burkus JK / 2003 / Is INFUSE bone graft superior to autograft bone? An integrated analysis of clinical trials using the LT-Cage lumbar tapered fusion device / J Spinal Disord Tech 16:113~122
Ripamonti U / 1994 / Periodontal regeneration: potential role of bone morphogenetic proteins / J Periodontal Res 29:225~235
Asahina I / 2014 / Bone morphogenetic proteins: their history and characteristics / J Hard Tissue Biol 23:283~286
Gauthier O / 1998 / Biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth / Biomaterials 19:133~139
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