지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제39권 제12호
- 발행연도
- 2017.12
- 수록면
- 1 - 6 (6page)
- DOI
- https://doi.org/10.1186/s40902-017-0138-9
이용수
초록· 키워드
오류제보하기
Background
The goal of this study is to evaluate complication and effectiveness of alveolar ridge augmentations using a hydroxyapatite-based alloplastic bony substitute with rhBMP-2.
Methods
A total of 10 patients (4 males, 6 females; 58.5?±?8.6 years) participated in this clinical research. Alveolar ridge augmentations were performed in edentulous (4 maxillary posterior, 5 mandibular posterior, and 1 mandibular anterior) regions. Anorganic bovine bone (ABB; Bio-Oss®, Geistlich Pharma AG, Wolhusen, Switzerland) was used as the bone graft material in the control group (n =?5)) while hydroxyapatite-based alloplastic bony substitute with rhBMP-2(HA+rhBMP-2; NOVOSIS®-Dent, CGBio Inc., Seongnam, Korea) was used in the experimental group (n =?5). In order to evaluate relative changes in bone volume and resorption rate of the bone graft material, CBCT radiographs were taken immediately and at 4 months after the bone graft in all subjects. Among the 10 patients, 8 received dental implants in Seoul National University Bundang Hospital, while the others received in local clinics. Bone specimens for further histomorphometric examinations were gained from these 8 patients using trephine burs during the implant placements. Clinical, radiographic, and histomorphometric evaluations were focused because of the small sample size.
Results
When CBCT radiographs were compared between immediately and at 4.07?±?0.13 months after the bone graft, both alveolar bone widths (ABB 2.52?±?0.18 mm, HA+rhBMP-2 1.75 ± 0.85 mm) and heights (ABB 1.68?±?0.17 mm, HA+rhBMP-2 1.57?±?0.28 mm) increased in the two groups. Resorption rates of transplanted bone graft material in the alveolar bone widths and heights were (ABB 29.7?±?8.8%, HA+rhBMP-2 31.5?±?7.4%) and (ABB 39.2?±?21.8%, HA+rhBMP-2 52.6?±?6.5%), respectively. Histomorphometrically, ABB group showed bone formation via osteoconduction and HA+rhBMP-2 group via osteoinduction. HA+rhBMP-2 group showed more bone formation around the bone graft materials than the ABB group. Postoperative complications were not found in all subjects.
Conclusions
Our study had following conclusions: (1) Ridge augmentations using HA+rhBMP-2 could be clinically useful to supplement implant placements in edentulous regions. (2) Serious postoperative complications related to the graft material did not occur
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
박슬지 / 2012 / 골유도재생술과 동시에 식립한 임플란트의 변연골 흡수량에 대한 후향적 고찰 / Maxillofacial Plastic Reconstructive Surgery 34(6):440~448
김영균 / 2013 / Tooth-derived bone graft material / 대한구강악안면외과학회지 39(3):103~111
황성택 / 2011 / 생체활성 유기물로 표면이 개질된 임플란트 개발 추이 분석 연구 / 대한치과보철학회지 49(03):254~262
엄인웅 / 2016 / Demineralized dentin matrix combined with recombinant human bone morphogenetic protein-2 in rabbit calvarial defects / 대한구강악안면외과학회지 42(2):90~98
Cheng H / 2003 / Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs) / J Bone Joint Surg Am 85(8):1544~1552
김영균 / 2013 / Tooth-derived bone graft material / 대한구강악안면외과학회지 39(3):103~111
황성택 / 2011 / 생체활성 유기물로 표면이 개질된 임플란트 개발 추이 분석 연구 / 대한치과보철학회지 49(03):254~262
엄인웅 / 2016 / Demineralized dentin matrix combined with recombinant human bone morphogenetic protein-2 in rabbit calvarial defects / 대한구강악안면외과학회지 42(2):90~98
Cheng H / 2003 / Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs) / J Bone Joint Surg Am 85(8):1544~1552
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