지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 191 - 196 (6page)
이용수
초록· 키워드
오류제보하기
Objectives: Beyond the original application approved by the U.S. Food and Drug Administration, recombinant human bone morphogenetic pro-tein-2 (rhBMP-2) is used for medication-related osteonecrosis of the jaw (MRONJ) treatment because of its bone remodeling enhancement proper-ties. The purpose of the study was to investigate the bone formation effect of rhBMP-2/absorbable collagen sponge (ACS) in patients with MRONJ. Materials and Methods: In this retrospective cohort study, 26 female patients diagnosed with MRONJ and who underwent mandibular se-questrectomy at Ajou University Dental Hospital from 2010 to 2018 were included. The experimental group was composed of 18 patients who received rhBMP-2/ACS after sequestrectomy, while the control group was composed of 8 patients who did not receive rhBMP-2/ACS after se-questrectomy. A total dose of 0.5 mg of rhBMP-2 was used in the experimental group at a concentration of 0.5 mg/mL. Follow-up panoramic X-rays were taken immediately after the surgery and more than 6 months after the surgery. Using those X-rays, a radiographic index of bone defect area was calculated using the modified Ihan Hren method, which measures radiographic density of the normal bone and the defect site. Results: This study suggests that rhBMP-2 contributes to new bone formation. The mean radiographic index immediately after surgery and more than 6 months after the surgery for the experimental group was 68.4% and 79.8%, respectively. The mean radiographic index immediately after surgery and more than 6 months after the surgery for the control group was 73.4% and 76.7%, respectively (Wilcoxon signed rank test, P>0.05). The mean radiographic index increased 11.4% in the experimental group and 3.27% in the control group (Mann–Whitney U-test, P<0.05). Conclusion: Based on the results, use of rhBMP-2/ACS on bone defect sites after sequestrectomy could be a successful strategy for treatment of MRONJ patients.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
이정근 / 2013 / Bisphosphonates-related osteonecrosis of the jaw in Korea: a preliminary report / 대한구강악안면외과학회지 39(1):9~13
Ruggiero SL / 2014 / American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update / J Oral Maxillofac Surg 72:1938~1956
Gómez Font R / 2008 / Osteochemonecrosis of the jaws due to bisphosphonate treatments. Update / Med Oral Patol Oral Cir Bucal 13:E318~E324
Ruggiero SL / 2009 / American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw -2009 update / Aust Endod J 35:119~130
Vescovi P / 2014 / Conservative surgical management of stage I bisphosphonate-related osteonecrosis of the jaw / Int J Dent 2014:107690
Ruggiero SL / 2014 / American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update / J Oral Maxillofac Surg 72:1938~1956
Gómez Font R / 2008 / Osteochemonecrosis of the jaws due to bisphosphonate treatments. Update / Med Oral Patol Oral Cir Bucal 13:E318~E324
Ruggiero SL / 2009 / American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw -2009 update / Aust Endod J 35:119~130
Vescovi P / 2014 / Conservative surgical management of stage I bisphosphonate-related osteonecrosis of the jaw / Int J Dent 2014:107690
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