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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 391 - 396 (6page)
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초록· 키워드
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ObjectiveRevascularization is critical for successful ovarian tissue transplantation. Vascular endothelial growth factor (VEGF) andangiopoietin-2 (angpt-2) are the principal mediators of neovascularization. This study was designed to assess VEGF andangpt-2 levels in cryopreserved ovarian tissue after heterotopic autotransplantation.
Methods Ovarian tissues harvested from ICR mice at 5 to 6 weeks of age were stratified as follows: no cryopreservation (controls,group I); vitrification in VFS-40 (vitrification, group II); and gradual freezing in dimethyl sulfoxide (slow-freezing, group III).
Frozen specimens were thawed at room temperature, assaying VEGF and angpt-2 levels 1 week after cryopreservation and 2weeks after autotransplantation.
Results VEGF and angpt-2 protein levels were significantly lower in cryopreserved ovaries of groups II and III than in controls (group I,P<0.05), whereas groups II and III did not differ significantly in this regard. After autotransplantation of cryopreserved ovariantissue, VEGF and angpt-2 protein levels did not differ significantly by technique but tended to be lower than correspondinglevels in controls.
Conclusion Expression of angiogenic factors in ovarian tissue is thought to vary by method of cryopreservation. Our findings indicatethat levels of angiogenic factors expressed in cryopreserved ovarian tissue after autotransplantation do not differ appreciablyfrom control levels, regardless of cryopreservation technique.
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참고문헌 (24)
참고문헌 신청
Abir R. / 2003 / Parameters affecting successful transplantation of frozenthawed human fetal ovaries into immunodeficient mice / Fertil Steril 80 : 421 ~ 428
Asahara T. / 1998 / Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization / Circ Res 83 : 233 ~ 240
Aubard Y. / 2001 / Are there indications for ovarian tissue cryopreservation? / Fertil Steril 76 : 414 ~ 415
Baird DT. / 1999 / Long-term ovarian function in sheep after ovariectomy and transplantation of autografts stored at-196 C / Endocrinology 140 : 462 ~ 471
Bedaiwy MA. / 2003 / Restoration of ovarian function after autotransplantation of intact frozen-thawed sheep ovaries with microvascular anastomosis / Fertil Steril 79 : 594 ~
Asahara T. / 1998 / Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization / Circ Res 83 : 233 ~ 240
Aubard Y. / 2001 / Are there indications for ovarian tissue cryopreservation? / Fertil Steril 76 : 414 ~ 415
Baird DT. / 1999 / Long-term ovarian function in sheep after ovariectomy and transplantation of autografts stored at-196 C / Endocrinology 140 : 462 ~ 471
Bedaiwy MA. / 2003 / Restoration of ovarian function after autotransplantation of intact frozen-thawed sheep ovaries with microvascular anastomosis / Fertil Steril 79 : 594 ~
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