지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 46 - 52 (7page)
이용수
초록· 키워드
오류제보하기
Objective: This study aimed to identify factors that affect in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR).
Methods: We reviewed 99 IVF cycles in 52 women with DOR between September 2010 and January 2015. DOR was defined as serum anti-Müllerian hormone level of <1.1 ng/dL or serum follicle-stimulating hormone level of ≥20 mIU/mL. Total 96 cycles in 50 patients were evaluated after excluding fertility preservation cases.
Results: The clinical pregnancy rate was 11.5% per cycle, and the total cancellation rate was 34.4%. Clinical pregnancy rate was significantly associated with the antral follicle count and the cause of the DOR. Age, serum anti-Müllerian hormone and follicle-stimulating hormone levels, antral follicle count, peak estradiol level, and the cause of DOR were significantly associated with cycle cancellation. However, history of previous ovarian surgery remained as a significant factor of clinical pregnancy (model 1: odds ratio [OR] 10.17, 95% confidence interval [CI] 1.46 to 70.84, P=0.019; model 2: OR 10.85, 95% CI 1.05 to 111.71, P=0.045). In cancellation models, idiopathic or previous chemotherapy group showed borderline significance (model 1: OR 3.76, 95% CI 0.83 to 17.04, P=0.086; model 2: OR 3.15, 95% CI 0.84 to 11.84, P=0.09).
Conclusion: DOR caused by previous ovarian surgery may show better pregnancy outcome, whereas that caused by chemotherapy could significantly increase the cycle cancellation rate. Furthermore, patients with DOR who previously received gonadotoxic agents may show reduced efficacy and increased risk of IVF cycle cancellation.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Bonilla-Musoles F / 2012 / Predicting ovarian reserve and reproductive outcome using antimullerian hormone (AMH) and antral follicle count (AFC) in patients with previous ass
Brodin T / 2013 / Antimullerian hormone levels are strongly associated with live-birth rates after assisted reproduction / J Clin Endocrinol Metab 98 : 1107 ~ 1114
Chan JL / 2015 / Outcomes of ovarian stimulation after treatment with chemotherapy / J Assist Reprod Genet 32 : 1537 ~ 1545
Cohen J / 2015 / Diminished ovarian reserve, premature ovarian failure, poor ovarian responder:a plea for universal definitions / J Assist Reprod Genet 32 : 1709 ~ 1712
Das M / 2012 / Ovarian reserve and response to IVF and in vitro maturation treatment following chemotherapy / Hum Reprod 27 : 2509 ~ 2514
Brodin T / 2013 / Antimullerian hormone levels are strongly associated with live-birth rates after assisted reproduction / J Clin Endocrinol Metab 98 : 1107 ~ 1114
Chan JL / 2015 / Outcomes of ovarian stimulation after treatment with chemotherapy / J Assist Reprod Genet 32 : 1537 ~ 1545
Cohen J / 2015 / Diminished ovarian reserve, premature ovarian failure, poor ovarian responder:a plea for universal definitions / J Assist Reprod Genet 32 : 1709 ~ 1712
Das M / 2012 / Ovarian reserve and response to IVF and in vitro maturation treatment following chemotherapy / Hum Reprod 27 : 2509 ~ 2514
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