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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제60권 제3호
발행연도
2019.1
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285 - 290 (6page)

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Purpose: To elucidate the correlation between ovarian reserve and the incidence of ectopic pregnancy (EP) following in vitro fertilizationand embryo transfer (IVF/ET) cycles. Materials and Methods: In this observational study, 430 fresh IVF/ET cycles were examined from patient data of two universityhospital infertility clinics. All included patients were positive for β-human chorionic gonadotropin (hCG) at 2 weeks after oocyteretrieval via controlled ovarian stimulation. For each cycle, information on age, duration of infertility, basal follicle stimulating hormone(FSH), anti-Müllerian hormone (AMH), days of ovarian stimulation, numbers of retrieved oocytes and transferred embryos,and pregnancy outcomes was collected. Patients with AMH lower than 1.0 ng/dL or basal FSH higher than 10 mIU/mL were classifiedinto the decreased ovarian reserve (DOR) group, and the remaining patients were classified into the normal ovarian reserve(NOR) group. Results: In total, 355 cycles showed NOR, and 75 cycles DOR. There were no significant differences between the DOR and NORgroups regarding intrauterine (74.7% vs. 83.4%, respectively) or chemical (14.7% vs. 14.1%, respectively) pregnancies. The DORgroup had a higher EP than that of NOR group [10.7% (8/75) vs. 2.5% (9/355), p=0.004]. In both univariate [odds ratio (OR) 5.6,95% confidence interval (CI) 1.4–9.6, p=0.011] and multivariate (adjusted OR 5.1, 95 % CI 1.1–18.7, p=0.012) analysis, DOR wasassociated with a higher risk of EP. Conclusion: DOR may be associated with a higher risk of EP in IVF/ET cycles with controlled ovarian stimulation. More carefulmonitoring may be necessary for pregnant women with DOR.

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