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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 376 - 382 (7page)
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Background: Acne is an inflammatory skin disorder caused by inflammatory biomarkers. Magnesium ascorbyl phosphate (MAP) is a stable precursor of vitamin C. It achieves a constant delivery of vitamin C into the skin and has antioxidative effects. Objective: We performed this study to evaluate the effect of MAP on the expression of inflammatory biomarkers in cultured sebocytes. Methods: Reverse transcription- polymerase chain reaction (RT-PCR) and enzyme- linked immunosorbent assay were performed for inflammatory cytokines and matrix metalloproteinases (MMPs) before and after treatment of cultured sebocytes with MAP (10−2 M), lipopolysaccharide (LPS) (5 μg/ml) and a combination of MAP and LPS. RT-PCR and western blotting were also performed for antimicrobial peptides (AMPs) and Toll-like receptor (TLR)-4 before and after treatment of cultured sebocytes with MAP, LPS, and a combination of MAP and LPS. Quantification of lipid peroxidation was also conducted.
Results: The increased expression of inflammatory cytokines after treatment of cultured sebocytes with LPS was decreased after treatment with MAP. MMPs, AMPs, and TLR-4 were decreased after treatment of cultured sebocytes with MAP and a combination of MAP and LPS, and increased after treatment of cultured sebocytes with LPS alone. Lipid peroxidation was significantly decreased after treatment of cultured sebocytes with MAP and a combination of MAP and LPS. MAP decreased the increased lipid peroxidation after treatment of cultured sebocytes with LPS. Conclusion: MAP may be an effective alternative agent to improve inflammatory reactions in acne.
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참고문헌 (18)
참고문헌 신청
Akitomo Y / 2003 / Effects of UV irradiation on the sebaceous gland and sebum secretion in hamsters / J Dermatol Sci 31 : 151 ~ 159
Alestas T / 2006 / Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands / J Mol Med (Berl) 84 : 75 ~ 87
Bojar RA / 2004 / Acne and Propionibacterium acnes / Clin Dermatol 22 : 375 ~ 379
Boni R / 2003 / Treatment of gram-negative folliculitis in patients with acne / Am J Clin Dermatol 4 : 273 ~ 276
Corbel M / 2001 / Repeated endotoxin exposure induces interstitial fibrosis associated with enhanced gelatinase (MMP-2 and MMP-9) activity / Inflamm Res 50 : 129 ~ 135
Alestas T / 2006 / Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands / J Mol Med (Berl) 84 : 75 ~ 87
Bojar RA / 2004 / Acne and Propionibacterium acnes / Clin Dermatol 22 : 375 ~ 379
Boni R / 2003 / Treatment of gram-negative folliculitis in patients with acne / Am J Clin Dermatol 4 : 273 ~ 276
Corbel M / 2001 / Repeated endotoxin exposure induces interstitial fibrosis associated with enhanced gelatinase (MMP-2 and MMP-9) activity / Inflamm Res 50 : 129 ~ 135
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