지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 581 - 587 (7page)
이용수
초록· 키워드
오류제보하기
Background: Although many therapeutic agents have been developed, only a few drugs are known to target multiple pathogenic factors in the treatment of acne. Objective: The purpose of this study was to identify a new drug candidate, platycodin D, which is a substance extracted from the root of Platycodon grandiflorum. Methods: Using western blotting and Cell Counting Kit-8 assay, we studied the effects of platycodin D on SEB-1 sebocytes, fibroblasts, and keratinocytes. We investigated its effects in view of lipogenesis, collagen production, anti-inflammatory activity, and dyskeratinization. Results: In SEB-1 sebocytes, platycodin D showed a sebosuppressive effect by downregulating ERK and insulin- like growth factor-1R/PI3K/Akt/sterol-regulatory element binding protein-1 signaling pathways. In addition, adiponectin, one of the adipokines responsible for sebum production, was decreased in platycodin D-treated SEB-1 sebocytes. In fibroblasts, platycodin D increased collagen production and reduced inflammation by inhibiting nuclear factor kappa B and matrix metalloproteinases. Platycodin D also showed anti-inflammatory effects on keratinocytes. It also suppressed keratin 16 expression induced by lipopolysaccharide. Furthermore, platycodin D showed no cytotoxicity on both SEB-1 sebocytes and fibroblasts. Conclusion: Our data demonstrate the clinical feasibility of platycodin D for acne treatment and the prevention of acne scarring by sebosuppressive and anti-inflammatory effects, as well as through an increase in collagen levels.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Li T / 2017 / Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor / Toxicol Appl Pharmacol 330:65~73
Wang B / 2016 / Platycodin D inhibits interleukin-13-induced the expression of inflammatory cytokines and mucus in nasal epithelial cells / Biomed Pharmacother 84:1108~1112
Lee EJ / 2012 / Platycodin D inhibits lipogenesis through $AMPK{\alpha}-PPAR{\gamma}2$ in 3T3-L1 cells and modulates fat accumulation in obese mice / Planta Med 78:1536~1542
Xu C / 2014 / Effects of platycodin D on proliferation, apoptosis and PI3K/Akt signal pathway of human glioma U251 cells / Molecules 19:21411~21423
Qin H / 2014 / Platycodin D, a triterpenoid saponin from platycodon grandiflorum, induces G2/M arrest and apoptosis in human hepatoma HepG2 cells by modulating the PI3K/Akt pathway / Tumour Biol 35:1267~1274
Wang B / 2016 / Platycodin D inhibits interleukin-13-induced the expression of inflammatory cytokines and mucus in nasal epithelial cells / Biomed Pharmacother 84:1108~1112
Lee EJ / 2012 / Platycodin D inhibits lipogenesis through
Xu C / 2014 / Effects of platycodin D on proliferation, apoptosis and PI3K/Akt signal pathway of human glioma U251 cells / Molecules 19:21411~21423
Qin H / 2014 / Platycodin D, a triterpenoid saponin from platycodon grandiflorum, induces G2/M arrest and apoptosis in human hepatoma HepG2 cells by modulating the PI3K/Akt pathway / Tumour Biol 35:1267~1274
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