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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 245 - 253 (9page)
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Background: Ginseng has been known in Korea as a healthsupportive herbal medicine from time immemorial. Essential oil isolated from fresh ginseng has been shown to display antibacterial and anti-inflammatory activities. Objective: The effects of red ginseng oil (RGO) on the lipopolysaccharide (LPS)-treated sebocytes and outer root sheath (ORS) cells were studied. Methods: The cultured cells were treated with either 0.1% dimethyl sulfoxide, 5 μg/ml LPS, 50 μg/ml RGO, or 5 μg/ml LPS plus 50 μg/ml RGO for 6 and 24 hours. RT-PCR, real-time PCR, enzyme-linked immunosorbent assay, western blot, and immunofluorescence staining were performed for the analysis of inflammatory cytokine. Results: RGO showed the increased gene and protein expression of inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α in the LPS-treated sebocytes and ORS cells. RGO also showed the increased protein expression of p-c-jun and p-JNK in the LPS-treated sebocytes and ORS cells. Gene expression of TLR2 was increased in LPS-treated sebocytes following treatment with RGO. Additionally, RGO resulted in an increased expression of LL-37 in the LPS-treated sebocytes and ORS cells. Moreover, it remarkably increased the production of sebum in LPS-treated sebocytes. Conclusion: RGO might be among the aggravating factors of acne vulgaris. It would be better to stop taking red ginseng in patients with inflammatory acne.
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참고문헌 (15)
참고문헌 신청
Seung-Hoon Baek / 2012 / Recent Methodology in Ginseng Analysis / Journal of Ginseng Research 36(2):119~134
강수원 / 2012 / Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System / Journal of Ginseng Research 36(4):354~368
Jinhee Kim / 2015 / Protective effect of Korean Red Ginseng against glucocorticoid-induced osteoporosis in vitro and in vivo / Journal of Ginseng Research 39(1):46~53
Prabuseenivasan S / 2006 / In vitro antibacterial activity of some plant essential oils / BMC Com-plement Altern Med 6:39
Bak MJ / 2012 / Red ginseng marc oil inhibits iNOS and COX-2 via NFκB and p38 pathways in LPS-stimulated RAW 264.7 macrophages / Molecules 17:13769~13786
강수원 / 2012 / Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System / Journal of Ginseng Research 36(4):354~368
Jinhee Kim / 2015 / Protective effect of Korean Red Ginseng against glucocorticoid-induced osteoporosis in vitro and in vivo / Journal of Ginseng Research 39(1):46~53
Prabuseenivasan S / 2006 / In vitro antibacterial activity of some plant essential oils / BMC Com-plement Altern Med 6:39
Bak MJ / 2012 / Red ginseng marc oil inhibits iNOS and COX-2 via NFκB and p38 pathways in LPS-stimulated RAW 264.7 macrophages / Molecules 17:13769~13786
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