지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 242 - 250 (9page)
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초록· 키워드
오류제보하기
Objectives：The present study is to investigate inflammatory markers and associated clinical factors between treatment resistant schizophrenia and non-treatment resistant schizophrenia.
Methods：Of the 116 schizophrenia subjects who were hospitalized for ac ute symptomatic treatment, 19 patients (16%) were treated with clozapine as a treatment resistant schizophrenia(TRS) and 97 patients(84%) were treated with other atypical antipsychotics as a non-treatment resistant schizophrenia(Non-TRS). Various inflammatory markers including C-reactive protein(CRP) and clinical factors were retrospectively evaluated with electrical medical records.
Results：There were significant differences between two groups in disease duration(p =0.015), number of admission (p =0.003), Clinical Global Impression(p ＜0.001) but other demographic and clinical variables including previous antipsychotics use did not show significant differences. In terms of hematologic profiles, TRS group demonstrated higher CRP level(p =0.006), lower neutrophil count p =0.012), and lower hemoglobin level(p =0.003) compared with non-TRS group. Body mass index was significantly correlated with CRP(r=0.318, p =0.001).
Conclusion：The elevated level of serum CRP in TRS suggests that treatment resistance in schizophrenia may be associated with inflammatory response. However, retrospective study design and small number of subjects could limit this interpretation.
Methods：Of the 116 schizophrenia subjects who were hospitalized for ac ute symptomatic treatment, 19 patients (16%) were treated with clozapine as a treatment resistant schizophrenia(TRS) and 97 patients(84%) were treated with other atypical antipsychotics as a non-treatment resistant schizophrenia(Non-TRS). Various inflammatory markers including C-reactive protein(CRP) and clinical factors were retrospectively evaluated with electrical medical records.
Results：There were significant differences between two groups in disease duration(p =0.015), number of admission (p =0.003), Clinical Global Impression(p ＜0.001) but other demographic and clinical variables including previous antipsychotics use did not show significant differences. In terms of hematologic profiles, TRS group demonstrated higher CRP level(p =0.006), lower neutrophil count p =0.012), and lower hemoglobin level(p =0.003) compared with non-TRS group. Body mass index was significantly correlated with CRP(r=0.318, p =0.001).
Conclusion：The elevated level of serum CRP in TRS suggests that treatment resistance in schizophrenia may be associated with inflammatory response. However, retrospective study design and small number of subjects could limit this interpretation.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (53)
참고문헌 신청
Suvisaari J / 2011 / Inflammation in psychotic disorders : a population-based study / Psychiatry Res 189:305~311
Singh B / 2014 / Role of C-reactive protein in schizophrenia : an overview / Psychiatry Res 216:277~285
Müller N / 2014 / Immunology of schizophrenia / J Neuroimmunomodulation 21:109~116
Müller N / 2012 / Inflammation in schizophrenia / Adv Protein Chem Struct Biol :49~68
Fineberg AM / 2013 / Inflammatory cytokines and neurological and neurocognitive alterations in the course of schizophrenia / Biol Psychiatry 73:951~966
Singh B / 2014 / Role of C-reactive protein in schizophrenia : an overview / Psychiatry Res 216:277~285
Müller N / 2014 / Immunology of schizophrenia / J Neuroimmunomodulation 21:109~116
Müller N / 2012 / Inflammation in schizophrenia / Adv Protein Chem Struct Biol :49~68
Fineberg AM / 2013 / Inflammatory cytokines and neurological and neurocognitive alterations in the course of schizophrenia / Biol Psychiatry 73:951~966
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