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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 52 - 59 (8page)
- DOI
- 10.16946/kjsr.2021.24.2.52
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초록· 키워드
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Objectives: Recent studies have reported that delayed initiation of clozapine can affect clinical response in patients with treatment- resistant schizophrenia (TRS). This study aimed to explore the relationship between delayed initiation of clozapine and acute treatment response.
Methods: Sixty-five inpatients with TRS who started clozapine for the first time were included through a retrospective chart review.
Acute treatment response was defined as a 30% reduction in the Positive and Negative Syndrome Scale score or a Clinical Global Impression of Improvement score of 1 (very much improved) or 2 (much improved) at 4 weeks after initiating clozapine.
Results: After meeting the TRS criteria, the mean delay for initiating clozapine was approximately 13.8 months. The delay was shorter in patients who showed a better response to clozapine in logistic regression analysis (p=0.037).
Conclusion: Our findings suggest that reducing the delay in initiating clozapine increases the effectiveness of clozapine in patients with TRS.
목차
등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Lehman AF / 2004 / Practice guideline for the treatment of patients with schizophrenia / Am J Psychiatry 161(2 Suppl):1~56
Lally J / 2019 / Treatment resistant schizophrenia-review and a call to action / Ir J Psychol Med 36:279~291
Howes OD / 2017 / Treatment-resistant schizophrenia:treatment response and resistance in psychosis (TRRIP) working group consensus guidelines on diagnosis and terminology / Am J Psychiatry 174:216~229
Gillespie AL / 2017 / Is treatment-resistant schizophrenia categorically distinct from treatmentresponsive schizophrenia? A systematic review / BMC Psychiatry 17:1~14
National Collaborating Centre for Mental Health (UK). / 2014 / Psychosis and schizophrenia in adults: treatment and management / National Institute for Health and Care Excellence (UK)
Lally J / 2019 / Treatment resistant schizophrenia-review and a call to action / Ir J Psychol Med 36:279~291
Howes OD / 2017 / Treatment-resistant schizophrenia:treatment response and resistance in psychosis (TRRIP) working group consensus guidelines on diagnosis and terminology / Am J Psychiatry 174:216~229
Gillespie AL / 2017 / Is treatment-resistant schizophrenia categorically distinct from treatmentresponsive schizophrenia? A systematic review / BMC Psychiatry 17:1~14
National Collaborating Centre for Mental Health (UK). / 2014 / Psychosis and schizophrenia in adults: treatment and management / National Institute for Health and Care Excellence (UK)
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