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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 901 - 909 (9page)
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Purpose Gemcitabine plus cisplatin (GemCis) is the standard first-line chemotherapy for patients with advanced biliary tract cancer (BTC). In ABC-02 study, the BTC patients received up to 6-8 cycles of 3-weekly GemCis; however, those without progression often receive more than 6-8 cycles. The clinical benefit of maintenance treatment in patients without progression is uncertain. Materials and Methods Advanced BTC patients treated with GemCis between April 2010 and February 2015 at Asan Medical Center, Seoul, Korea, were retrospectively analysed. The patients without progression after 6-8 cycles were stratified according to further treatment i.e., with or without further cycles of GemCis (maintenance vs. observation groups). The primary endpoint was overall survival (OS) and progression-free survival (PFS). Results Among the 740 BTC patients in the initial screen, 231 cases (31.2%) were eligible for analysis (111 in the observation group, 120 in the maintenance group). The median OS from the GemCis initiation was 20.5 months (95% confidence interval [CI], 15.4 to 25.6) and 22.4 months (95% CI, 17.0 to 27.8) in the observation and maintenance groups, respectively (p=0.162). The median PFS was 10.4 months (95% CI, 7.0 to 13.8) and 13.2 months (95% CI, 11.3 to 15.2), respectively (p=0.320). Conclusion GemCis maintenance is not associated with an improved survival outcome.
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참고문헌 (14)
참고문헌 신청
Patel T / 2001 / Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States / Hepatology 33:1353~1357
Siegel RL / 2017 / Cancer statistics, 2017 / CA Cancer J Clin 67:7~30
Howlader N / 1975 / SEER cancer statistics review, 1975-2013
Edge SB / 2010 / The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM / Ann Surg Oncol 17:1471~1474
Valle J / 2010 / Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer / N Engl J Med 362:1273~1281
Siegel RL / 2017 / Cancer statistics, 2017 / CA Cancer J Clin 67:7~30
Howlader N / 1975 / SEER cancer statistics review, 1975-2013
Edge SB / 2010 / The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM / Ann Surg Oncol 17:1471~1474
Valle J / 2010 / Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer / N Engl J Med 362:1273~1281
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