지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 102 - 107 (6page)
이용수
초록· 키워드
오류제보하기
Background and Purpose We aimed to determine the association between the annual changes in dopamine transporter (DAT) availability as measured by 123I-ioflupane (123I-FP-CIT) single-photon-emission computed tomography and single-nucleotide polymorphisms (SNPs) known to be risk factors in Parkinson’s disease (PD). Methods In total, 150 PD patients were included from the Parkinson’s Progression Markers Initiative database. Specific SNPs that are associated with PD were selected for genotyping. SNPs that were not in Hardy-Weinberg equilibrium or whose minor allele frequency was less than 0.05 were excluded. Twenty-three SNPs met the inclusion criteria for this study. The Kruskal- Wallis test was used to compare annual percentage changes in DAT availability for three subgroups of SNP. Results None of the 23 SNPs exerted a statistically significant effect (p<0.0022) on the decline of DAT availability in PD patients. However, we observed trends of association (p<0.05) between three SNPs of two genes with the annual percentage change in DAT availability: 1) rs199347 on the putamen (p=0.0138), 2) rs356181 on the caudate nucleus (p=0.0105), and 3) rs3910105 on the caudate nucleus (p=0.0374). A post-hoc analysis revealed that DAT availability was reduced the most for 1) the putamen in the CC genotype of rs199347 (vs. CT, p=0.0199; vs. TT, p= 0.0164), 2) the caudate nucleus in the TT genotype of rs356181 (vs. CC, p=0.0081), and 3) the caudate nucleus in the CC genotype of rs3910105 (vs. TT, p=0.0317). Conclusions Significant trends in the associations between three SNPs and decline of DAT availability in PD patients have been discovered.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of rs3910105 in the Synuclein Gene on Dopamine Transporter Availability in Healthy Subjects
Yonsei Medical Journal
2018 .01
-
Establishment of a Tm-shift Method for Detection of Cat-Derived Hookworms
Parasites, Hosts and Diseases
2019 .02
-
Cancer Risk Score Prediction Based on a Single-Nucleotide Polymorphism Network
Healthcare Informatics Research
2022 .07
-
Replication Association Study between RBC Indices and Genetic Variants in Korean Population
대한의생명과학회지
2019 .06
-
Heterogeneous Patterns of Striatal Dopamine Loss in Patients with Young- versus Old-Onset Parkinson’s Disease: Impact on Clinical Features
Journal Of Movement Disorders
2019 .01
-
Non-Association between rs7903146 and rs12255372 Polymorphisms in Transcription Factor 7-Like 2 Gene and Type 2 Diabetes Mellitus in Jahrom City, Iran
Diabetes and Metabolism Journal
2015 .01
-
Evidence for Association between the Brain-Derived Neurotrophic Factor Gene and Panic Disorder: A Novel Haplotype Analysis
PSYCHIATRY INVESTIGATION
2015 .01
-
Are Podoplanin Gene Polymorphisms Associated with Atopic Dermatitis in Koreans?
Annals of Dermatology
2015 .01
-
Programmed Cell Death-Ligand 1 (PD-L1) gene Single Nucleotide Polymorphism in Graves’ Disease and Hashimoto’s Thyroiditis in Korean Patients
Endocrinology and Metabolism
2021 .01
-
Consolidation of a Learned Skill Correlates with Dopamine SPECT Uptake in Early Parkinson’s Disease
Journal of Clinical Neurology
2018 .01
-
Comparison of single nucleotide polymorphisms and short tandem repeats as markers for differentiating between donors and recipients in solid organ transplantation
Clinical Transplantation and Research
2021 .01
-
Recapitulation of Genome-wide Association Study on Chronic Periodontitis in a Korean Population
대한의생명과학회지
2017 .06
-
Linkage and Association Analyses of Schizophrenia with Genetic Variations on Chromosome 22q11 in Koreans
PSYCHIATRY INVESTIGATION
2016 .01
-
Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived Neurotrophic Factor with Posttraumatic Stress Disorder
PSYCHIATRY INVESTIGATION
2018 .01
-
Genetic Polymorphism of MDM2 SNP309 in Patients with Helicobacter Pylori-Associated Gastritis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus
Diabetes and Metabolism Journal
2021 .11
-
Sodium nitroprusside on acute cardiogenic pulmonary edema in dogs: case reports
Korean Journal of Veterinary Research(대한수의학회지)
2022 .09
-
Single Nucleotide Polymorphisms Associated with Alcohol-Induced Flushing Syndrome in Korean Population
대한법의학회지
2019 .01
-
196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients
PSYCHIATRY INVESTIGATION
2018 .01
-
한국인 기관지 천식 虛證, 實證 환자와 EDN1 유전자 다형성과의 상관성 연구
대한한방내과학회지
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0