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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 787 - 792 (6page)
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초록· 키워드
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Purpose: The present study investigated associations between dopamine transporter (DAT) availability and α-synuclein levels incerebrospinal fluid, as well as synuclein gene (SNCA) transcripts, and the effect of single nucleotide polymorphism of SNCA onDAT availability in healthy subjects. Materials and Methods: The study population comprised healthy controls who underwent 123I-FP-CIT single-photon emissioncomputed tomography screening. Five SNCA probes were used to target the boundaries of exon 3 and exon 4 (SNCA-E3E4), transcriptswith a long 3’UTR region (SNCA-3UTR-1, SNCA-3UTR-2), transcripts that skip exon 5 (SNCA-E4E6), and the rare shorttranscript isoforms that comprise exons 1–4 (SNCA-007). Results: In total, 123 healthy subjects (male 75, female 48) were included in this study. DAT availability in the caudate nucleus(p=0.0661) and putamen (p=0.0739) tended to differ according to rs3910105 genotype. In post-hoc analysis, DAT availability inthe putamen was lower in subjects of TT genotype than those of CC/CT (p=0.0317). DAT availability in the caudate nucleus alsoshowed a trend similar to that in the putamen (p=0.0597). Subjects of CT genotype with rs3910105 showed negative correlationswith DAT availability in the putamen with SNCA-E3E4 (p=0.037, rho=-0.277), and SNCA-E4E6 (p=0.042, rho=-0.270), but notthose of CC/TT genotypes. Conclusion: This is the first study to investigate the association of rs3910105 in SNCA with DAT availability. rs3910105 had an effecton DAT availability, and the correlation between DAT availability and SNCA transcripts were significant in CT genotypes ofrs3910105.
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Spillantini MG / 1998 / alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies / Proc Natl Acad Sci U S A 95:6469~6473
Politis M / 2014 / Neuroimaging in Parkinson disease: from research setting to clinical practice / Nat Rev Neurol 10:708~722
Park E / 2012 / A new era of clinical dopamine transporter imaging using 123I-FP-CIT / J Nucl Med Technol 40:222~228
Booth TC / 2015 / The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 1 / AJNR Am J Neuroradiol 36:229~235
Marshall V / 2003 / Role of dopamine transporter imaging in routine clinical practice / Mov Disord 18:1415~1423
Politis M / 2014 / Neuroimaging in Parkinson disease: from research setting to clinical practice / Nat Rev Neurol 10:708~722
Park E / 2012 / A new era of clinical dopamine transporter imaging using 123I-FP-CIT / J Nucl Med Technol 40:222~228
Booth TC / 2015 / The role of functional dopamine-transporter SPECT imaging in parkinsonian syndromes, part 1 / AJNR Am J Neuroradiol 36:229~235
Marshall V / 2003 / Role of dopamine transporter imaging in routine clinical practice / Mov Disord 18:1415~1423
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