지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives Psychological resilience is the ability to cope with stress. The genetic background behind psychological resilience is not much known. The serotonin transporter and dopamine transporter are implicated in stress related psychology and emotional processing. The aim of this study is to investigate a possible genetic role of functional polymorphisms of serotonin and dopamine transporters for psychological resilience. Methods A total of 951 healthy adult subjects were included. Psychological resilience was measured using Connor-Davidson Resilience Scale (CD-RISC). Genotyping was performed for serotonin transporter gene(SERT) promoter variable number tandem repeat (VNTR) and dopamine transporter gene(DAT1) 3'-untranslated region (UTR) VNTR. Genetic association analysis was conducted between genotypes and the CD-RISC score. Results No genetic association was observed for SERT promoter VNTR or DAT1 3'-UTR VNTR with CD-RISC score. No genetic interaction between SERT promoter VNTR and DAT1 3'-UTR VNTR with CD-RISC score was detected. Conclusions Either serotonin or dopamine transporter did not seem to play a significant role for psychological resilience in this sample.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Campbell-Sills L / 2006 / Relationship of resilience to personality, coping, and psychiatric symptoms in young adults / Behav Res Ther 44:585~599
Caspi A / 2003 / Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene / Science 301:386~389
Charney DS / 2004 / Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress / Am J Psychiatry 161:195~216
Haskett ME / 2006 / Diversity in adjustment of maltreated children: factors associated with resilient functioning / Clin Psychol Rev 26:796~812
Benetti C / 2006 / Affect-regulated indirect effects of trait anxiety and trait resilience on self-esteem / Pers Individ Dif 41:341~352
Caspi A / 2003 / Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene / Science 301:386~389
Charney DS / 2004 / Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress / Am J Psychiatry 161:195~216
Haskett ME / 2006 / Diversity in adjustment of maltreated children: factors associated with resilient functioning / Clin Psychol Rev 26:796~812
Benetti C / 2006 / Affect-regulated indirect effects of trait anxiety and trait resilience on self-esteem / Pers Individ Dif 41:341~352
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