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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제45권 제2호
- 발행연도
- 2015.4
- 수록면
- 101 - 114 (14page)
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초록· 키워드
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Drug transporters play an important role in theabsorption, distribution, and elimination of drugs and theirmetabolites. Drug transporters can be subdivided into solutecarrier (SLC) and ATP-binding cassette (ABC) family.
SLC transporters are secondary active transporters thatwork as uptake transporters, whereas ABC transporters areprimary active transporters that work as efflux transporters.
Knockout animal models that lack a specific transportergene(s) are excellent tools to study the function of a drugtransporter. In recent times, various gene knockout animalmodels have been developed that have significantly contributedin defining the roles of these transporters in vivo;for example, the roles of multidrug resistance protein,breast cancer resistance protein, multidrug resistance?relatedproteins, organic anionic transporters, organic cationictransporters, and organic anion transportingpolypeptides have received great attention after theirknockout models were generated. In this review, we aim tosummarize the in vivo roles of drug transporters based onstudies using knockout animal models.
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참고문헌 (135)
참고문헌 신청
Adachi M / 2002 / Therapeutic and biological importance of getting nucleotides out of cells: a case for the ABC transporters, MRP4 and 5 / Adv Drug Deliv Rev 54(10):1333~1342
Agarwal S / 2011 / The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain / J Pharmacol Exp Ther 336(1):223~233
Agarwal S / 2012 / Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-glycoprotein (Pgp) breast cancer resistance protein (Bcrp) and P-gp/Bcrp knockout mice / Drug Metab Dispos 40(6):1164~1169
Alvarez AI / 2011 / Bioavailability of the glucuronide and sulfate conjugates of genistein and daidzein in breast cancer resistance protein 1 knockout mice / Drug Metab Dispos 39(11):2008~2012
Belinsky MG / 2007 / Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage / Cancer Res 67(1):262~268
Agarwal S / 2011 / The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain / J Pharmacol Exp Ther 336(1):223~233
Agarwal S / 2012 / Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-glycoprotein (Pgp) breast cancer resistance protein (Bcrp) and P-gp/Bcrp knockout mice / Drug Metab Dispos 40(6):1164~1169
Alvarez AI / 2011 / Bioavailability of the glucuronide and sulfate conjugates of genistein and daidzein in breast cancer resistance protein 1 knockout mice / Drug Metab Dispos 39(11):2008~2012
Belinsky MG / 2007 / Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage / Cancer Res 67(1):262~268
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