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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 311 - 317 (7page)
이용수
초록· 키워드
오류제보하기
The transport systems for metals play crucial roles in both the physiological functions of essential metals and the toxic effects of hazardous metals in mammals and plants. In mammalian cells, Zn transporters such as ZIP8 and ZIP14 have been found to function as the transporters for Mn(II) and Cd(II), contributing to the maintenance of Mn homeostasis and metallothionein-independent transports of Cd, respectively. In rice, the Mn transporter OsNramp5 expressed in the root is used for the uptake of Cd from the soil. Japan began to cultivate OsNramp5 mutant rice, which was found to accumulate little Cd, to prevent Cd accumulation. Inorganic trivalent arsenic (As(III)) is absorbed into mammalian cells via aquaglyceroporin, a water and glycerol channel. The ortholog of aquaporin in rice, OsLsi1, was found to be an Si transporter expressed in rice root, and is responsible for the absorption of soil As(III) into the root. Since rice is a hyperaccumulator of Si, higher amounts of As(III) are incorporated into rice compared to other plants. Thus, the transporters of essential metals are also utilized to incorporate toxic metals in both mammals and plants, and understanding the mechanisms of metal transports is important for the development of mitigation strategies against food contamination.
목차
Abstract
ROLES OF METAL TRANSPORTERS IN TOXICOMETALLOMICS
TRANSPORTERS FOR CELLULAR INCORPORATION OF Cd AND Mn IN MAMMALS
ABSORPTION OF SOIL Cd IN RICE VIA A Mn TRANSPORTER
TRANSPORTERS FOR CELLULAR INCORPORATION OF As IN MAMMALS
ABSORPTIONS OF As VIA Si TRANSPORTER IN RICE AND ITS TRADE-OFF PROBLEM WITH Cd
CONCLUSIONS
REFERENCES
참고문헌 (52)
참고문헌 신청
Haraguchi, H. / 2017 / Metallomics: the history over the last decade and a future outlook / Metallomics 9:1001~1013
Hara, T. / 2017 / Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis / J. Physiol. Sci 67:283~301
Klaassen, C. D. / 2009 / Metallothionein protection of cadmium toxicity / Toxicol. Appl. Pharmacol 238:215~220
Sabolić, I. / 2010 / Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs / Biometals 23:897~926
Wolff, N. A. / 2006 / Megalin-dependent internalization of cadmiummetallothionein and cytotoxicity in cultured renal proximal tubule cells / J. Pharmacol. Exp. Ther 318:782~791
Hara, T. / 2017 / Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis / J. Physiol. Sci 67:283~301
Klaassen, C. D. / 2009 / Metallothionein protection of cadmium toxicity / Toxicol. Appl. Pharmacol 238:215~220
Sabolić, I. / 2010 / Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs / Biometals 23:897~926
Wolff, N. A. / 2006 / Megalin-dependent internalization of cadmiummetallothionein and cytotoxicity in cultured renal proximal tubule cells / J. Pharmacol. Exp. Ther 318:782~791
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