지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 387 - 392 (6page)
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초록· 키워드
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Background: Alopecia areata (AA), a chronic, relapsing hairloss disorder, is considered to be a T-cell-mediated autoimmune disease. Cold-inducible RNA-binding protein (CIRP) belongs to a family of cold-shock proteins that respond to cold stress, and has been identified as a damage-associated molecular pattern (DAMP) molecule that triggers the inflammatory response. Recent studies have shown that highmobility group box 1, another DAMP molecule, is elevated in serum and scalp tissue of AA patients, suggesting a relationship between DAMP molecules and the pathogenesis of AA. Objective: To investigate the clinical significance of serum CIRP levels in AA. Methods: The serum levels of CIRP were compared between 68 patients with AA and 20 healthy controls. Additionally, the correlation between CIRP level and various clinical parameters was evaluated. Results: The serum CIRP levels were significantly higher in AA patients compared to healthy subjects. Moreover, there was an association between the serum CIRP level and clinical characteristics, such as disease duration and disease activity. However, there was no significant difference in the serum CIRP level among the clinical types of AA (AA multiplex, alopecia totalis, and alopecia universalis). Conclusion: These results suggest that CIRP may play a significant role in the pathogenesis of AA and could be a potential biologic marker for monitoring the disease activity of AA.
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참고문헌 (29)
참고문헌 신청
Gilhar A / 2012 / Alopecia areata / N Engl J Med 366:1515~1525
Islam N / 2015 / The autoimmune basis of alopecia areata : a comprehensive review / Autoimmun Rev 14:81~89
Milgraum SS / 1987 / Alopecia areata, endocrine function, and autoantibodies in patients 16 years of age or younger / J Am Acad Dermatol 17:57~61
Chu SY / 2011 / Comorbidity profiles among patients with alopecia areata : the importance of onset age, a nationwide populationbased study / J Am Acad Dermatol 65:949~956
Chen CH / 2016 / Follow-up study on the relationship between alopecia areata and risk of autoimmune diseases / J Dermatol 43:228~229
Islam N / 2015 / The autoimmune basis of alopecia areata : a comprehensive review / Autoimmun Rev 14:81~89
Milgraum SS / 1987 / Alopecia areata, endocrine function, and autoantibodies in patients 16 years of age or younger / J Am Acad Dermatol 17:57~61
Chu SY / 2011 / Comorbidity profiles among patients with alopecia areata : the importance of onset age, a nationwide populationbased study / J Am Acad Dermatol 65:949~956
Chen CH / 2016 / Follow-up study on the relationship between alopecia areata and risk of autoimmune diseases / J Dermatol 43:228~229
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