지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 378 - 390 (13page)
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Purpose The purpose of this study was to identify novel plasma biomarkers for distinguishing nasopharyngeal carcinoma (NPC) patients from healthy individuals who have positive Epstein-Barr virus (EBV) viral capsid antigen (VCA-IgA). Materials and Methods One hundred seventy-four plasma cytokines were analyzed by a Cytokine Array in eight healthy individuals with positive EBV VCA-IgA and eight patients with NPC. Real-time polymerase chain reaction, Western blotting, enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry were employed to detect the expression levels of macrophage migration inhibitory factor (MIF) and CC chemokine ligand 3 (CCL3) in NPC cell lines and tumor tissues. Plasma MIF and CCL3 were measured by ELISA in 138 NPC patients, 127 EBV VCA-IgA negative (VN) and 100 EBV VCA-IgA positive healthy donors (VP). Plasma EBV VCA-IgA was determined by immunoenzymatic techniques. Results Thirty-four of the 174 cytokines varied significantly between the VP and NPC group. Plasma MIF and CCL3 were significantly elevated in NPC patients compared with VN and VP. Combination of MIF and CCL3 could be used for the differential diagnosis of NPC from VN cohort (area under the curve [AUC], 0.913; sensitivity, 90.00%; specificity, 80.30%), and combination of MIF, CCL3, and VCA-IgA could be used for the differential diagnosis of NPC from VP cohort (AUC, 0.920; sensitivity, 90.00%; specificity, 84.00%), from (VN+VP) cohort (AUC, 0.961; sensitivity, 90.00%; specificity, 92.00%). Overexpressions of MIF and CCL3 were observed in NPC plasma, NPC cell lines and NPC tissues. Conclusion Plasma MIF, CCL3, and VCA-IgA combination significantly improves the diagnostic specificity of NPC in high-risk individuals.
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참고문헌 (29)
참고문헌 신청
Razak AR / 2010 / Nasopharyngeal carcinoma : the next challenges / Eur J Cancer 46:1967~1978
Cao SM / 2006 / Clinical analysis of 1, 142 hospitalized cantonese patients with nasopharyngeal carcinoma / Ai Zheng 25:204~208
Chen CJ / 1990 / Multiple risk factors of nasopharyngeal carcinoma : Epstein-Barr virus, malarial infection, cigarette smoking and familial tendency / Anticancer Res 10:547~553
Liu JP / 2006 / Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma / Cell Res 16:809~817
Lo KW / 2004 / Focus on nasopharyngeal carcinoma / Cancer Cell 5:423~428
Cao SM / 2006 / Clinical analysis of 1, 142 hospitalized cantonese patients with nasopharyngeal carcinoma / Ai Zheng 25:204~208
Chen CJ / 1990 / Multiple risk factors of nasopharyngeal carcinoma : Epstein-Barr virus, malarial infection, cigarette smoking and familial tendency / Anticancer Res 10:547~553
Liu JP / 2006 / Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma / Cell Res 16:809~817
Lo KW / 2004 / Focus on nasopharyngeal carcinoma / Cancer Cell 5:423~428
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