Clinicopathologic Characteristics and Prognosis of Tongue Squamous Cell Carcinoma in Patients with and without a History of Radiation for Nasopharyngeal Carcinoma: A Matched Case-Control Study

Peng Zhang; Li Zhang; Hui Liu; Lei Zhao; Yong Li; Jing-Xian Shen; Qing Liu; Meng-Zhong Liu; Mian Xi

추천

검색

자료유형: 학술저널

저자정보: Peng Zhang (Sun Yat-sen University Cancer Center China) Li Zhang (Sun Yat-sen University Cancer Center China) Hui Liu (Sun Yat-sen University Cancer Center China) Lei Zhao (Sun Yat-sen University Cancer Center China) Yong Li (Sun Yat-sen University Cancer Center China) Jing-Xian Shen (un Yat-sen University Cancer Center China) Qing Liu (un Yat-sen University Cancer Center China) Meng-Zhong Liu (un Yat-sen University Cancer Center China) Mian Xi (un Yat-sen University Cancer Center China)

저널정보: 대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제49권 제3호

발행연도: 2017.7

수록면: 695 - 705 (11page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose Previous studies reported an association between an increased risk of tongue cancer and radiation treatment for nasopharyngeal carcinoma (NPC). This study compared the clinicopathologic characteristics and outcomes of tongue squamous cell carcinoma (TSCC) in patients with and without a history of radiotherapy for NPC. Materials and Methods From 1965 to 2009, a total of 73 patients were diagnosed with TSCC with a history of radiotherapy for NPC. The patients were matched in a 1:3 ratio with patients with sporadic TSCC according to age, sex, and year of the TSCC diagnosis. The primary endpoint was the overall survival. Results The median interval from NPC to TSCC was 82 months. The NPC survivors were more likely to be diagnosed with a more advanced T classification, less likely to have lymph node involvement, and more likely to have the tumor located in the dorsum of the tongue than sporadic TSCC. Regarding the histologic characteristics, the NPC survivors were more likely to have a weak lymphocytic host response, low tumor budding, and low risk of a worse pattern of invasion. The sporadic TSCC patients had a better overall survival (hazard ratio, 0.690; p=0.033) than the NPC survivors. In competing risks analysis, the cumulative incidence functions for the competing event (documented non-tongue cancer death) were significantly higher in the NPC survivors (Gray’s test, p=0.001). Conclusion TSCC patients with a history of radiotherapy for NPC appear to have particular clinicopathologic features, a poorer survival, and are more likely to die from non-tongue cancer causes than those with sporadic TSCC.

#Tongue neoplasms #Second primary cancer #Nasopharyngeal carcinoma #Prognosis #Morbidity

참고문헌 (26)

참고문헌 신청

Wei WI / 2005 / Nasopharyngeal carcinoma / Lancet 365:2041~2054

Lee AW / 2005 / Treatment results for nasopharyngeal carcinoma in the modern era : the Hong Kong experience / Int J Radiat Oncol Biol Phys 61:1107~1116

Tham IW / 2009 / Treatment of nasopharyngeal carcinoma using intensity-modulated radiotherapy-the national cancer centre singapore experience / Int J Radiat Oncol Biol Phys 75:1481~1486

Travis LB / 2013 / Aetiology, genetics and prevention of secondary neoplasms in adult cancer survivors / Nat Rev Clin Oncol 10:289~301

Chen MC / 2008 / The incidence and risk of second primary cancers in patients with nasopharyngeal carcinoma : a population-based study in Taiwan over a 25-year period(1979-2003) / Ann Oncol 19:1180~1186

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!