지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 108 - 115 (8page)
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초록· 키워드
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Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a well-known side effect of certain drugs that are used to influence bone metabolism to treat osteometabolic disease or cancers. The purpose of our study was to investigate how high-concentration and low-concentration bisphosphonate (BP) intake affects the disease severity. Materials and Methods: Data collected from the medical records of 52 patients treated with BPs, antiresorptive, antiangiogenic drugs and diagnosed with MRONJ were included in this study. Age, sex, type of systemic disease, type of drug, duration of drug treatment, jaw area with MRONJ, drug administration protocol, and MRONJ clinical and radiological findings were obtained. Patients were divided into two groups: anti-neoplastic (Group I, n=23) and anti-osteoporotic (Group II, n=29). Statistical evaluations were performed using the IBM SPSS ver. 21.0 program. Results: In both groups, more females had MRONJ. MRONJ was found in the mandibles of 30 patients (Group I, n=14; Group II, n=16). When we classified patients according to the American Association of Oral and Maxillofacial Surgeons staging system, significant differences were seen between groups (χ2=12.23, P<0.01). More patients with advanced stage (stage 2-3) MRONJ were found in Group I (60.9%). Conclusion: According to our results, high-concentration BP intake, age and duration of drug intake increased disease severity.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Marx RE / 2003 / Pamidronate(Aredia)and zoledronate(Zometa)induced avascular necrosis of the jaws : a growing epidemic / J Oral Maxillofac Surg 61:1115~1117
Ruggiero SL / 2014 / American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update / J Oral Maxillofac Surg 72:1938~1956
Rosen LS / 2004 / Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors : a randomized, Phase III, double-blind, placebo-controlled trial / Cancer 100:2613~2621
Benhamou CL / 2007 / Effects of osteoporosis medications on bone quality / Joint Bone Spine 74:39~47
Woo SB / 2006 / Narrative [corrected] review : bisphosphonates and osteonecrosis of the jaws / Ann Intern Med 144:753~761
Ruggiero SL / 2014 / American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update / J Oral Maxillofac Surg 72:1938~1956
Rosen LS / 2004 / Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors : a randomized, Phase III, double-blind, placebo-controlled trial / Cancer 100:2613~2621
Benhamou CL / 2007 / Effects of osteoporosis medications on bone quality / Joint Bone Spine 74:39~47
Woo SB / 2006 / Narrative [corrected] review : bisphosphonates and osteonecrosis of the jaws / Ann Intern Med 144:753~761
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