지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: After recognition of 3D printing and injectable hydrogel as a critical issue in tissue/organ engineering and regenerative medicine society, many hydrogels as bioinks have been developed worldwide by using polymeric biomaterials such as gelatin, alginate, hyaluronic acid and others. Even though some gels have shown good performances in 3D bioprinting, still their performances do not meet the requirements enough to be used as a bioink in tissue engineering. Method: In this study, a hydrogel consisting of three biocompatible biomaterials such as hyaluronic acid (HA), hydroxyethyl acrylate (HEA) and gelatin-methacryloyl, i.e. HA-g-pHEA-gelatin gel, has been evaluated for its possibility as a bioprinting gel, a bioink. Hydrogel synthesis was obtained by graft polymerization of HEA to HA and then grafting of gelatin- methacryloyl via radical polymerization mechanism. Physical and biological properties of the HA-based hydrogels fabricated with different concentrations of methacrylic anhydride (6 and 8%) for gelatin-methacryloylation have been evaluated such as swelling, rheology, morphology, cell compatibility, and delivery of small molecular dimethyloxalylglycine. Printings of HA-g-pHEA-Gelatin gel and its bioink with bone cell loaded in lattice forms were also evaluated by using home-built multi-material (3D bio-) printing system. Conclusion: The experimental results demonstrated that the HA-g-pHEA-gelatin hydrogel showed both stable rheology properties and excellent biocompatibility, and the gel showed printability in good shape. The bone cells in bioinks of the lattice-printed scaffolds were viable. This study showed HA-g-pHEA-Gelatin gel’s potential as a bioink or its tissue engineering applications in injectable and 3D bioprinting forms.
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참고문헌 (35)
참고문헌 신청
자나르다난 고피나단 / 2018 / Recent trends in bioinks for 3D printing / 생체재료학회지 22(2):105~119
Sean V Murphy / 2014 / 3D bioprinting of tissues and organs / Nature Biotechnology 32(8):773~785
자나르다난 고피나단 / 2018 / Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications / 조직공학과 재생의학 15(5):531~546
Bon Kang Gu / 2016 / 3-dimensional bioprinting for tissue engineering applications / 생체재료학회지 20(2):88~95
Cen Chen / 2016 / Research trends in biomimetic medical materials for tissue engineering: 3D bioprinting, surface modification, nano/micro-technology and clinical aspects in tissue engineering of cartilage and bone / 생체재료학회지 20(2):96~102
Sean V Murphy / 2014 / 3D bioprinting of tissues and organs / Nature Biotechnology 32(8):773~785
자나르다난 고피나단 / 2018 / Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications / 조직공학과 재생의학 15(5):531~546
Bon Kang Gu / 2016 / 3-dimensional bioprinting for tissue engineering applications / 생체재료학회지 20(2):88~95
Cen Chen / 2016 / Research trends in biomimetic medical materials for tissue engineering: 3D bioprinting, surface modification, nano/micro-technology and clinical aspects in tissue engineering of cartilage and bone / 생체재료학회지 20(2):96~102
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