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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 525 - 534 (10page)
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Objectives: Reduced glucose utilization in the main parts of the brain involved in memory is a major cause of Alzheimer’s disease, in which ketone bodies are used as the only and effective alternative energy source of glucose. This study examined the effects of a low-carbohydrate and high-fat (LCHF) diet supplemented with a ketogenic nutrition drink on cognitive function and physical activity in the elderly at high risk for dementia.
Methods: The participants of this study were 28 healthy elderly aged 60-91 years showing a high risk factor of dementia or whose Korean Mini-Mental State Examination (K-MMSE) score was less than 24 points. Over 3 weeks, the case group was given an LCHF diet with nutrition drinks consisting of a ketone/non-ketone ratio of 1.73:1, whereas the control group consumed well-balanced nutrition drinks while maintaining a normal diet. After 3 weeks, K-MMSE, body composition, urine ketone bodies, and physical ability were all evaluated.
Results: Urine ketone bodies of all case group subjects were positive, and K-MMSE score was significantly elevated in the case group only (p=0.021). Weight and BMI were elevated in the control group only (p<0.05). Grip strength was elevated in all subjects (p<0.01), and measurements of gait speed and one leg balance were improved only in the case group (p<0.05).
Conclusions: We suggest that adherence to the LCHF diet supplemented with a ketogenic drink could possibly influence cognitive and physical function in the elderly with a high risk factor for dementia. Further, we confirmed the applicability of this dietary intervention in the elderly based on its lack of any side effects or changes in nutritional status.
Methods: The participants of this study were 28 healthy elderly aged 60-91 years showing a high risk factor of dementia or whose Korean Mini-Mental State Examination (K-MMSE) score was less than 24 points. Over 3 weeks, the case group was given an LCHF diet with nutrition drinks consisting of a ketone/non-ketone ratio of 1.73:1, whereas the control group consumed well-balanced nutrition drinks while maintaining a normal diet. After 3 weeks, K-MMSE, body composition, urine ketone bodies, and physical ability were all evaluated.
Results: Urine ketone bodies of all case group subjects were positive, and K-MMSE score was significantly elevated in the case group only (p=0.021). Weight and BMI were elevated in the control group only (p<0.05). Grip strength was elevated in all subjects (p<0.01), and measurements of gait speed and one leg balance were improved only in the case group (p<0.05).
Conclusions: We suggest that adherence to the LCHF diet supplemented with a ketogenic drink could possibly influence cognitive and physical function in the elderly with a high risk factor for dementia. Further, we confirmed the applicability of this dietary intervention in the elderly based on its lack of any side effects or changes in nutritional status.
목차
ABSTRACT
서론
연구대상 및 방법
결과
고찰
요약 및 결론
References
참고문헌 (31)
참고문헌 신청
Rye YH / 2014 / Diagnostic usefulness of brain FDG-PET for Alzheimer’s dementia / National Evidence-based Healthcare Collaborating Agency :1~197
Sorbi S / 2012 / EFNS?ENS guidelines on the diagnosis and management of disorders associated with dementia / Eur J Neurol 19(9):1159~1179
Ministry of Health & Welfare / 2008 / Nationwide study on the prevalence of dementia in Korean elders :146~157
Volkert D / 2015 / ESPEN guidelines on nutrition in dementia / Am J Clin Nutr 34(6):1052~1073
Alzheimer’s association / 2016 / 2016 Alzheimer’s disease facts and figures / Alzheimer Dement 12(4):459~509
Sorbi S / 2012 / EFNS?ENS guidelines on the diagnosis and management of disorders associated with dementia / Eur J Neurol 19(9):1159~1179
Ministry of Health & Welfare / 2008 / Nationwide study on the prevalence of dementia in Korean elders :146~157
Volkert D / 2015 / ESPEN guidelines on nutrition in dementia / Am J Clin Nutr 34(6):1052~1073
Alzheimer’s association / 2016 / 2016 Alzheimer’s disease facts and figures / Alzheimer Dement 12(4):459~509
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