지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Intracranial arterial dolichoectasia (IADE), also known as dilatative arteriopathy of the brain vessels, refers to an increase in the length and diameter of at least one intracranial artery, and accounts for approximately 12% of all patients with stroke. However, the association of IADE with stroke is usually unclear. Cerebral small vessel disease (CSVD) is characterized by pathological changes in the small vessels. Clinically, patients with CSVD can be asymptomatic or present with stroke or cognitive decline. In the past 20 years, a series of studies have strongly promoted an understanding of the association between IADE and CSVD from clinical and pathological perspectives. It has been proposed that IADE and CSVD may be attributed to abnormal vascular remodeling driven by an abnormal matrix metalloproteinase/tissue inhibitor of metalloproteinase pathway. Also, IADErelated hemodynamic changes may result in initiation or progression of CSVD. Additionally, genetic factors are implicated in the pathogenesis of IADE and CSVD. Patients with Fabry’s disease and late-onset Pompe’s disease are prone to developing concomitant IADE and CSVD, and patients with collagen IV alpha 1 or 2 gene (COL4A1/COL4A2) and forkhead box C1 (FOXC1) variants present with IADE and CSVD. Race, strain, familial status, and vascular risk factors may be involved in the pathogenesis of IADE and CSVD. As well, experiments in mice have pointed to genetic strain as a predisposing factor for IADE and CSVD. However, there have been few direct genetic studies aimed towards determining the association between IADE and CSVD. In the future, more clinical and basic research studies are needed to elucidate the causal relationship between IADE and CSVD and the related molecular and genetic mechanisms.
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참고문헌 (71)
참고문헌 신청
Pico F / 2015 / Pathophysiology, presentation, prognosis, and management of intracranial arterial dolichoectasia / Lancet Neurol 14:833~845
Del Brutto VJ / 2017 / Intracranial arterial dolichoectasia / Front Neurol 8:344
Gutierrez J / 2011 / Dolichoectasia : an evolving arterial disease / Nat Rev Neurol 7:41~50
Wolters FJ / 2013 / Clinical course and treatment of vertebrobasilar dolichoectasia : a systematic review of the literature / Neurol Res 35:131~137
Smoker WR / 1986 / Highresolution computed tomography of the basilar artery: 1. Normal size and position / AJNR Am J Neuroradiol 7:55~60
Del Brutto VJ / 2017 / Intracranial arterial dolichoectasia / Front Neurol 8:344
Gutierrez J / 2011 / Dolichoectasia : an evolving arterial disease / Nat Rev Neurol 7:41~50
Wolters FJ / 2013 / Clinical course and treatment of vertebrobasilar dolichoectasia : a systematic review of the literature / Neurol Res 35:131~137
Smoker WR / 1986 / Highresolution computed tomography of the basilar artery: 1. Normal size and position / AJNR Am J Neuroradiol 7:55~60
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