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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 86 - 95 (10page)
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The red-crowned crane (Grus japonensis) is an endangered, large-bodied crane native to East Asia. It is a traditional symbol of longevity and its long lifespan has been confirmed both in captivity and in the wild. Lifespan in birds is known to be positively correlated with body size and negatively correlated with metabolic rate, though the genetic mechanisms for the red-crowned crane’s long lifespan have not previously been investigated. Using whole genome sequencing and comparative evolutionary analyses against the grey-crowned crane and other avian genomes, including the long-lived common ostrich, we identified redcrowned crane candidate genes with known associations with longevity. Among these are positively selected genes in metabolism and immunity pathways (NDUFA5, NDUFA8, NUDT12, SOD3, CTH , RPA1, PHAX, HNMT , HS2ST1 , PPCDC , PSTK CD8B, GP9, IL-9R, and PTPRC). Our analyses provide genetic evidence for low metabolic rate and longevity, accompanied by possible convergent adaptation signatures among distantly related large and long-lived birds. Finally, we identified low genetic diversity in the red-crowned crane, consistent with its listing as an endangered species, and this genome should provide a useful genetic resource for future conservation studies of this rare and iconic species.
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참고문헌 (51)
참고문헌 신청
Accardi, G. / 2018 / Immune-inflammatory responses in the elderly : an update / Immun. Ageing 15:11
Adzhubei, I. A. / 2010 / A method and server for predicting damaging missense mutations / Nat. Methods 7:248~249
Ashburner, M. / 2000 / Gene ontology : tool for the unification of biology / The Gene Ontology Consortium. Nat. Genet 25:25~29
Boulon, S. / 2004 / PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli / Mol. Cell 16:777~787
Chen, W. / 2012 / Behavioural alterations in domestication process : comparative studies between wild, captive and inbred red-crowned cranes(Grus japonensis) / J. Anim. Vet. Adv 11:2711~2715
Adzhubei, I. A. / 2010 / A method and server for predicting damaging missense mutations / Nat. Methods 7:248~249
Ashburner, M. / 2000 / Gene ontology : tool for the unification of biology / The Gene Ontology Consortium. Nat. Genet 25:25~29
Boulon, S. / 2004 / PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli / Mol. Cell 16:777~787
Chen, W. / 2012 / Behavioural alterations in domestication process : comparative studies between wild, captive and inbred red-crowned cranes(Grus japonensis) / J. Anim. Vet. Adv 11:2711~2715
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