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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 581 - 589 (9page)
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Neurons have multiple dendrites and single axon. This neuronal polarity is gradually established during early processes of neuronal differentiation: generation of multiple neurites (stages 1-2); differentiation (stage 3) and maturation (stages 4-5) of an axon and dendrites. In this study, we demonstrated that the neuron-specific n-glycosylated protein NELL2 is important for neuronal polarization and axon growth using cultured rat embryonic hippocampal neurons. Endogenous NELL2 expression was gradually increased in parallel with the progression of developmental stages of hippocampal neurons, and overexpression of NELL2 stimulated neuronal polarization and axon growth. In line with these results, knockdown of NELL2 expression resulted in deterioration of neuronal development, including inhibition of neuronal development progression, decreased axon growth and increased axon branching. Inhibitor against extracellular signal-regulated kinase (ERK) dramatically inhibited NELL2-induced progression of neuronal development and axon growth. These results suggest that NELL2 is an important regulator for the morphological development for neuronal polarization and axon growth.
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참고문헌 (33)
참고문헌 신청
Acebes, A. / 2000 / Cellular and molecular features of axon collaterals and dendrites / Trends Neurosci 23:557~565
Barnes, A. P. / 2009 / Establishment of axon-dendrite polarity in developing neurons / Annu. Rev. Neurosci 32:347~381
Chao, M. V / 2003 / Neurotrophins and their receptors : a convergence point for many signaling pathways / Nat. Rev. Neurosci 4:299~309
Cheng, P. L. / 2011 / Self-amplifying autocrine actions of BDNF in axon development / Proc. Natl. Acad. Sci. U. S. A 108:18430~18435
Choi, E. J. / 2010 / Estrogen-dependent transcription of the NEL-like 2(NELL2)gene and its role in protection from cell death / J. Biol. Chem 285:25074~25084
Barnes, A. P. / 2009 / Establishment of axon-dendrite polarity in developing neurons / Annu. Rev. Neurosci 32:347~381
Chao, M. V / 2003 / Neurotrophins and their receptors : a convergence point for many signaling pathways / Nat. Rev. Neurosci 4:299~309
Cheng, P. L. / 2011 / Self-amplifying autocrine actions of BDNF in axon development / Proc. Natl. Acad. Sci. U. S. A 108:18430~18435
Choi, E. J. / 2010 / Estrogen-dependent transcription of the NEL-like 2(NELL2)gene and its role in protection from cell death / J. Biol. Chem 285:25074~25084
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