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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 837 - 845 (9page)
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Background A synapse is a fundamental signaling component that facilitates neuronal connectivity and information processing in the brain. Dynamic changes in the number, size, and functionality of synapse are induced by extensive signaling networks and structural proteins, which are stimulated on various neuronal activities. Changes in the expression level of synaptic proteins depend upon the physiological and pathological conditions at transcriptional, post-transcriptional, and post-translational levels. MicroRNAs (miRNAs) have not only emerged as pivotal gene expression regulators in neurons, but also in diverse cell types. miRNAs are evolutionarily conserved small non-coding RNAs that modulate mRNA stability and protein synthesis by interacting with 3′-untranslated region (3′-UTR) of mRNAs. Often, miRNA expression is limited to specific neuronal compartments such as axons, dendrites, and cell body to locally regulate protein synthesis in response to various stimuli. Objective Increasing evidences suggest that miRNAs are involved in the regulation of neuronal proliferation, differentiation, migration, development, and many other processes. This article reviews recent findings on the role of miRNAs in synapse formation and function. Conclusions Many studies have elucidated the role of miRNAs in diverse neuronal physiological and pathological processes. A better understanding of the mechanisms involved in miRNA functioning at the synapse will be beneficial in formulating novel therapeutic strategies.
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참고문헌 (65)
참고문헌 신청
Bagni C / 2005 / From mRNP trafficking to spine dysmorphogenesis : the roots of fragile X syndrome / Nat Rev Neurosci 6:376~387
Bassell GJ / 2008 / Fragile X syndrome : loss of local mRNA regulation alters synaptic development and function / Neuron 60:201~214
Ben-Ari Y / 2012 / The Yin and Yen of GABA in brain development and operation in health and disease / Front Cell Neurosci 6:45
Biever A / 2019 / Local translation in neuronal processes / Curr Opin Neurobiol 57:141~148
Bischoff A / 2015 / A global microRNA screen identifies regulators of the ErbB receptor signaling network / Cell Commun Signal 13:5
Bassell GJ / 2008 / Fragile X syndrome : loss of local mRNA regulation alters synaptic development and function / Neuron 60:201~214
Ben-Ari Y / 2012 / The Yin and Yen of GABA in brain development and operation in health and disease / Front Cell Neurosci 6:45
Biever A / 2019 / Local translation in neuronal processes / Curr Opin Neurobiol 57:141~148
Bischoff A / 2015 / A global microRNA screen identifies regulators of the ErbB receptor signaling network / Cell Commun Signal 13:5
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