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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 880 - 888 (9page)
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초록· 키워드
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Inherited peripheral neuropathy is a heterogeneous group of peripheral neurodegenerative disorders including Charcot?Marie?Tooth disease. Many peripheral neuropathies often accompany impaired axonal construction and function. To study the molecular and cellular basis of axon-defective peripheral neuropathy, we explore the possibility of using Caenorhabditis elegans, a powerful nematode model equipped with a variety of genetics and imaging tools. In search of potential candidates of C. elegans peripheral neuropathy models, we monitored the movement and the body posture patterns of 26 C. elegans strains with disruption of genes associated with various peripheral neuropathies and compiled a database of their phenotypes. Our assay showed that movement features of the worms with mutations in HSPB1, MFN2, DYNC1H1, and KIF1B human homologues are significantly different from the control strain, suggesting they are viable candidates for C. elegans peripheral neuropathy models.
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참고문헌 (42)
참고문헌 신청
Acunzo, J. / 2012 / Small heat shock proteins HSP27(HspB1), αB-crystallin(HspB5)and HSP22(HspB8)as regulators of cell death / Int. J. Biochem. Cell Biol 44:1622~1631
Antonellis, A. / 2003 / Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V / Am. J. Hum. Genet 72:1293~1299
Baek, J. H. / 2002 / Using machine vision to analyze and classify Caenorhabditis elegans behavioral phenotypes quantitatively / J. Neurosci. Methods 118:9~21
Ben Arous, J. / 2009 / Molecular and sensory basis of a food related two-state behavior in C. elegans / PLoS One 4:e7584
Bragato, C. / 2016 / Zebrafish as a model to investigate dynamin 2-related diseases / Sci. Rep 6:20466
Antonellis, A. / 2003 / Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V / Am. J. Hum. Genet 72:1293~1299
Baek, J. H. / 2002 / Using machine vision to analyze and classify Caenorhabditis elegans behavioral phenotypes quantitatively / J. Neurosci. Methods 118:9~21
Ben Arous, J. / 2009 / Molecular and sensory basis of a food related two-state behavior in C. elegans / PLoS One 4:e7584
Bragato, C. / 2016 / Zebrafish as a model to investigate dynamin 2-related diseases / Sci. Rep 6:20466
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