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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 160 - 167 (8page)
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초록· 키워드
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The determinant factors of an organism’s size during animal development have been explored from various angles but remain partially understood. In Caenorhabditis elegans, many genes affecting cuticle structure, cell growth, and proliferation have been identified to regulate the worm’s overall morphology, including body size. While various mutations in those genes directly result in changes in the morphological phenotypes, there is still a need for established, clear, and distinct standards to determine the apparent abnormality in a worm’s size and shape. In this study, we measured the body length, body width, terminal bulb length, and head size of mutant worms with reported Dumpy (Dpy), Small (Sma) or Long (Lon) phenotypes by plotting and comparing their respective ratios of various parameters. These results show that the Sma phenotypes are proportionally smaller overall with mild stoutness, and Dpy phenotypes are significantly stouter and have disproportionally small head size. This study provides a standard platform for determining morphological phenotypes designating and annotating mutants that exhibit body shape variations, defining the morphological phenotype of previously unexamined mutants.
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참고문헌 (28)
참고문헌 신청
Avery, L. / 2003 / Food transport in the C. elegans pharynx / J. Exp. Biol 206:2441~2457
Bar, D. Z. / 2016 / Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor / Proc. Natl. Acad. Sci. U. S. A. 113:E4620~E4629
Brenner, S. / 1974 / The genetics of Caenorhabditis elegans / Genetics 77:71~94
C. elegans Deletion Mutant Consortium / 2012 / Large-scale screening for targeted knockouts in the Caenorhabditis elegans genome / G3 (Bethesda) 2:1415~1425
정기화 / 2020 / A Database of Caenorhabditis elegans Locomotion and Body Posture Phenotypes for the Peripheral Neuropathy Model / Molecules and Cells 43(10):880~888
Bar, D. Z. / 2016 / Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor / Proc. Natl. Acad. Sci. U. S. A. 113:E4620~E4629
Brenner, S. / 1974 / The genetics of Caenorhabditis elegans / Genetics 77:71~94
C. elegans Deletion Mutant Consortium / 2012 / Large-scale screening for targeted knockouts in the Caenorhabditis elegans genome / G3 (Bethesda) 2:1415~1425
정기화 / 2020 / A Database of Caenorhabditis elegans Locomotion and Body Posture Phenotypes for the Peripheral Neuropathy Model / Molecules and Cells 43(10):880~888
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