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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 10 - 16 (7page)
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When peripheral axons are damaged, neuronal injury signaling pathways induce transcriptional changes that support axon regeneration and consequent functional recovery. The recent development of bioinformatics techniques has allowed for the identification of many of the regeneration-associated genes that are regulated by neural injury, yet it remains unclear how global changes in transcriptome are coordinated. In this article, we review recent studies on the epigenetic mechanisms orchestrating changes in gene expression in response to nerve injury. We highlight the importance of epigenetic mechanisms in discriminating efficient axon regeneration in the peripheral nervous system and very limited axon regrowth in the central nervous system and discuss the therapeutic potential of targeting epigenetic regulators to improve neural recovery.
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참고문헌 (57)
참고문헌 신청
Abe, N. / 2008 / Nerve injury signaling / Curr. Opin. Neurobiol. 18:276~283
Abe, N. / 2010 / Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves / J. Biol. Chem. 285:28034~28043
Bareyre, F. M. / 2011 / In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration / Proc. Natl. Acad. Sci. USA 108:6282~6287
Ben-Tov Perry, R. / 2012 / Subcellular knockout of importin β1perturbs axonal retrograde signaling / Neuron 75:294~305
Bode, A. G. / 2004 / Post-translational modification of p53 in tumorigenesis / Nat. Rev. Cancer 4:793~805
Abe, N. / 2010 / Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves / J. Biol. Chem. 285:28034~28043
Bareyre, F. M. / 2011 / In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration / Proc. Natl. Acad. Sci. USA 108:6282~6287
Ben-Tov Perry, R. / 2012 / Subcellular knockout of importin β1perturbs axonal retrograde signaling / Neuron 75:294~305
Bode, A. G. / 2004 / Post-translational modification of p53 in tumorigenesis / Nat. Rev. Cancer 4:793~805
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