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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 31 - 41 (11page)
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Neuroinflammation is known as the main mechanism implicated in the advancement of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. The main feature of neuroinflammation is associated with the activation of microglia. The activated microglia increase proinflammatory cytokine production and induce progressive neuronal cell death. Citrus flavonoids show neuroprotective effects that are associated with the anti-inflammatory action of flavonoids in neurodegenerative diseases. Among these citrus flavonoids, kaempferol, naringin, and nobiletin show inhibitory effects on nuclear factor-κB and mitogen-activated protein kinase signaling pathways that can modulate inflammatory conditions in microglial cells. In the present review, we present the anti-inflammatory activities of citrus flavonoids and therapeutic potential of flavonoids as neuroprotective agents.
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참고문헌 (70)
참고문헌 신청
Jeremy P.E. Spencer / 2012 / Neuroinflammation: Modulation by flavonoids and mechanisms of action / Molecular Aspects of Medicine 33(1):83~97
Christopher K. Glass / 2010 / Mechanisms Underlying Inflammation in Neurodegeneration / Cell 140(6):918~934
Mark P. Mattson / 2004 / Pathways towards and away from Alzheimer's disease / Nature 430(7000):631~639
Kina Höglund / 2014 / Molecular biomarkers of neurodegeneration / Expert Review of Molecular Diagnostics 13(8):845~861
Barry Halliwell / 1992 / Reactive Oxygen Species and the Central Nervous System / Journal of Neurochemistry 59(5):1609~1623
Christopher K. Glass / 2010 / Mechanisms Underlying Inflammation in Neurodegeneration / Cell 140(6):918~934
Mark P. Mattson / 2004 / Pathways towards and away from Alzheimer's disease / Nature 430(7000):631~639
Kina Höglund / 2014 / Molecular biomarkers of neurodegeneration / Expert Review of Molecular Diagnostics 13(8):845~861
Barry Halliwell / 1992 / Reactive Oxygen Species and the Central Nervous System / Journal of Neurochemistry 59(5):1609~1623
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