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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제19권 제5호
- 발행연도
- 2015.9
- 수록면
- 441 - 449 (9page)
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초록· 키워드
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Flavonoids are plant pigments that have been demonstrated to exert various pharmacological effects including anti-cancer, anti-diabetic, anti-atherosclerotic, anti-bacterial, and anti-inflammatory activities.
However, the molecular mechanisms in terms of exact target proteins of flavonoids are not fully elucidated yet. In this study, we aimed to evaluate the anti-inflammatory mechanism of scutellarein (SCT), a flavonoid isolated from Erigeron breviscapus, Clerodendrum phlomidis and Oroxylum indicum Vent that have been traditionally used to treat various inflammatory diseases in China and Brazil.
For this purpose, a nitric oxide (NO) assay, polymerase chain reaction (PCR), nuclear fractionation, immunoblot analysis, a kinase assay, and an overexpression strategy were employed. Scutellarein significantly inhibited NO production in a dose-dependent manner and reduced the mRNA expression levels of inducible NO synthase (iNOS) and tumor necrosis factor (TNF)-α in lipopolysaccharide (LPS)-activated RAW264.7 cells. In addition, SCT also dampened nuclear factor (NF)-κB-driven expression of a luciferase reporter gene upon transfection of a TIR-domain-containing adapter-inducing interferon-β (TRIF) construct into Human embryonic kidney 293 (HEK 293) cells; similarly, NF-κ B nuclear translocation was inhibited by SCT. Moreover, the phosphorylation levels of various upstream signaling enzymes involved in NF-κB activation were decreased by SCT treatment in LPS-treated RAW264.7 cells. Finally, SCT strongly inhibited Src kinase activity and also inhibited the autophosphorylation of overexpressed Src. Therefore, our data suggest that SCT can block the inflammatory response by directly inhibiting Src kinase activity linked to NF-κB activation.
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등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Kinne RW / 2000 / Macrophages in rheumatoid arthritis / Arthritis Res 2:189~202
Ross R / 1999 / Atherosclerosis--an inflammatory disease / N Engl J Med 340:115~126
Liu SF / 2006 / NF-kappa B activation as a pathological mechanism of septic shock and inflammation / Am J Physiol Lung Cell Mol Physiol 290:L622~L645
Stuhlmüller B / 2000 / Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis / Arthritis Rheum 43:775~790
Fujiwara N / 2005 / Macrophages in inflammation / Curr Drug Targets Inflamm Allergy 4:281~286
Ross R / 1999 / Atherosclerosis--an inflammatory disease / N Engl J Med 340:115~126
Liu SF / 2006 / NF-kappa B activation as a pathological mechanism of septic shock and inflammation / Am J Physiol Lung Cell Mol Physiol 290:L622~L645
Stuhlmüller B / 2000 / Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis / Arthritis Rheum 43:775~790
Fujiwara N / 2005 / Macrophages in inflammation / Curr Drug Targets Inflamm Allergy 4:281~286
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