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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제3호
- 발행연도
- 2020.1
- 수록면
- 237 - 245 (9page)
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초록· 키워드
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Background: Cancer cells displaying aberrant metabolism switch energy production from oxidative phosphorylation to glycolysis. Measure of glucose standardized uptake value (SUV) by positron emission tomography (PET), used for staging of adenocarcinoma in highrisk patients, can reflect cellular use of the glycolysis pathway. The transcription factor, FoxM1 plays a role in regulation of glycolytic genes. Cancer cell transformation is driven by mutations in tumor suppressor genes such as TP53 and STK11 and oncogenes such as KRAS and EGFR. In this study, SUV and FOXM1 gene expression were compared in the background of selected cancer gene mutations. Methods: Archival tumor tissue from cases of lung adenocarcinoma were analyzed. SUV was collected from patient records. FOXM1 gene expression was assessed by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Gene mutations were detected by allele-specific PCR and gene sequencing. Results: SUV and FOXM1 gene expression patterns differed in the presence of single and coexisting gene mutations. Gene mutations affected SUV and FOXM1 differently. EGFR mutations were found in tumors with lower FOXM1 expression but did not affect SUV. Tumors with TP53 mutations had increased SUV (p = .029). FOXM1 expression was significantly higher in tumors with STK11 mutations alone (p < .001) and in combination with KRAS or TP53 mutations (p < .001 and p = .002, respectively). Conclusions: Cancer gene mutations may affect tumor metabolic activity. These observations support consideration of tumor cell metabolic state in the presence of gene mutations for optimal prognosis and treatment strategy.
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참고문헌 (25)
참고문헌 신청
Tomasini P / 2019 / Effect of coexisting KRAS and TP53 mutations in patients treated with chemotherapy for nonsmall-cell lung cancer / Clin Lung Cancer 20:e338~e345
Charu Aggarwal / 2018 / Influence of TP53 mutation on survival in patients with advanced EGFR-mutant non-smallcell lung cancer / JCO Precision Oncology (2):1~29
Ding M / 2019 / A comprehensive analysis of WGCNA and serum metabolomics manifests the lung cancer-associated disordered glucose metabolism / J Cell Biochem 120:10855~10863
Cairns RA / 2011 / Regulation of cancer cell metabolism / Nat Rev Cancer 11:85~95
Soga T / 2013 / Cancer metabolism : key players in metabolic reprogramming / Cancer Sci 104:275~281
Charu Aggarwal / 2018 / Influence of TP53 mutation on survival in patients with advanced EGFR-mutant non-smallcell lung cancer / JCO Precision Oncology (2):1~29
Ding M / 2019 / A comprehensive analysis of WGCNA and serum metabolomics manifests the lung cancer-associated disordered glucose metabolism / J Cell Biochem 120:10855~10863
Cairns RA / 2011 / Regulation of cancer cell metabolism / Nat Rev Cancer 11:85~95
Soga T / 2013 / Cancer metabolism : key players in metabolic reprogramming / Cancer Sci 104:275~281
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