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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제4호
- 발행연도
- 2020.1
- 수록면
- 310 - 317 (8page)
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초록· 키워드
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Background: The presence of telomerase reverse transcriptase (TERT) promoter mutations have been associated with a poor prognosis in patients with papillary thyroid carcinomas (PTC). The frequency of TERT promoter mutations varies widely depending on the population and the nature of the study. Methods: Data were prospectively collected in 724 consecutive patients who underwent thyroidectomy for PTC from 2018 to 2019. Molecular testing for BRAF V600E and TERT promoter mutations was performed in all cases. Results: TERT promoter alterations in two hotspots (C228T and C250T) and C216T were found in 16 (2.2%) and 4 (0.6%) of all PTCs, respectively. The hotspot mutations were significantly associated with older age at diagnosis, larger tumor size, extrathyroidal extension, higher pathologic T category, lateral lymph node metastasis, and higher American Thyroid Association recurrence risk. The patients with C216T variant were younger and had a lower American Thyroid Association recurrence risk than those with hotspot mutations. Concurrent BRAF V600E was found in 19 of 20 cases with TERT promoter mutations. Of 518 microcarcinomas measuring ≤ 1.0 cm in size, hotspot mutations and C216T variants were detected in five (1.0%) and three (0.6%) cases, respectively. Conclusions: Our study indicates a low frequency of TERT promoter mutations in Korean patients with PTC and supports previous findings that TERT promoter mutations are more common in older patients with unfavorable clinicopathologic features and BRAF V600E. TERT promoter mutations in patients with microcarcinoma are uncommon and may have a limited role in risk stratification. The C216T variant seems to have no clinicopathologic effect on PTC.
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참고문헌 (28)
참고문헌 신청
Vaccarella S / 2016 / Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis / N Engl J Med 375:614~617
Ahn HS / 2016 / Thyroid cancer screening in South Korea increases detection of papillary cancers with no impact on other subtypes or thyroid cancer mortality / Thyroid 26:1535~1540
Ahn HS / 2014 / Korea's thyroid-cancer"epidemic" : screening and overdiagnosis / N Engl J Med 371:1765~1767
정규원 / 2019 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2016 / Cancer Research and Treatment 51(2):417~430
Park S / 2016 / Association between screening and the thyroid cancer"epidemic"in South Korea : evidence from a nationwide study / BMJ 355:i5745
Ahn HS / 2016 / Thyroid cancer screening in South Korea increases detection of papillary cancers with no impact on other subtypes or thyroid cancer mortality / Thyroid 26:1535~1540
Ahn HS / 2014 / Korea's thyroid-cancer"epidemic" : screening and overdiagnosis / N Engl J Med 371:1765~1767
정규원 / 2019 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2016 / Cancer Research and Treatment 51(2):417~430
Park S / 2016 / Association between screening and the thyroid cancer"epidemic"in South Korea : evidence from a nationwide study / BMJ 355:i5745
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Null Association between BRAF V600E Mutation and Tumor Recurrence in Patients with Papillary Thyroid Microcarcinoma in South Korea
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