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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제52권 제1호
- 발행연도
- 2018.1
- 수록면
- 14 - 20 (7page)
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Background: Trophoblast antigen 2 (TROP2) is a human trophoblast cell-surface glycoprotein that is overexpressed in several types of epithelial cancers, and is suggested to be associated with an unfavorable prognosis. BRAF mutations are the most common genetic alteration in papillary thyroid carcinoma (PTC). We evaluated the correlation between TROP2 expression and BRAF mutation in PTC. Methods: First, we carried out pyrosequencing for BRAF mutations and immunohistochemistry for TROP2 expression with a tissue microarray consisting of 52 PTC cases. Membranous staining in at least 5% of tumor cells was designated as positive staining and we analyzed the relationship between TROP2 expression and diverse clinicopathological factors, including BRAF mutation. Second, we tested TROP2 mRNA expression in three thyroid cancer cell lines with BRAF mutations (BCPAP, SNU790, and 8505C) and a normal thyroid cell line. Additionally, we checked TROP2 protein levels in a normal thyroid cell line after introduction of the BRAF V600E mutation. Results: In this study, 21 of 26 cases with BRAF mutation showed TROP2 immunoreactivity, whereas all 26 cases without BRAF mutation showed no immunoreactivity for TROP2 with a statistically significant difference (p < .001). Upregulation of TROP2 mRNA was observed in all three thyroid cancer cell lines, but not in the normal thyroid cell line. Interestingly, however, the TROP2 expression was increased in the normal thyroid cell line after introduction of the BRAF V600E mutation. Conclusions: Based on these results, we concluded that TROP2 expression is significantly associated with BRAF mutation and that TROP2 immunohistochemistry could be used for predicting BRAF mutations or diagnosing papillary thyroid carcinoma.
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참고문헌 (23)
참고문헌 신청
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Shvartsur A / 2015 / Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications / Genes Cancer 6:84~105
McDougall AR / 2015 / Trop2: from development to disease / Dev Dyn 244:99~109
Lipinski M / 1981 / Human trophoblast cell-surface antigens defined by monoclonal antibodies / Proc Natl Acad Sci U S A 78:5147~5150
Fang YJ / 2009 / Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer / Int J Colorectal Dis 24:875~884
Shvartsur A / 2015 / Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications / Genes Cancer 6:84~105
McDougall AR / 2015 / Trop2: from development to disease / Dev Dyn 244:99~109
Lipinski M / 1981 / Human trophoblast cell-surface antigens defined by monoclonal antibodies / Proc Natl Acad Sci U S A 78:5147~5150
Fang YJ / 2009 / Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer / Int J Colorectal Dis 24:875~884
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