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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 556 - 561 (6page)
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Background: Acral melanomas are known to have a low frequency of BRAF mutation, in contrary to higher KIT mutation. Recently, VE1 immunostaining was reported to have a good correlation with BRAF mutation status. Objective: We aimed to evaluate the clinicopathological features of BRAF-mutated acral melanomas and validate the correlation of the VE1 immunohistochemical stains in those cases. Methods: The clinical features (age, sex, anatomical site), and histopathological characteristics of 41 patients with acral melanoma were evaluated. We performed a next-generation sequencing to detect BRAF mutation status. We also determined the correlation of VE1 immunohistochemical staining with BRAF mutation status. Results: Among 19 acral melanomas with BRAF mutation, common histopathological subtype was acral lentiginous melanoma (8/19, 42%) and nodular melanoma (8/19, 42%) and superficial spreading melanoma (3/19, 16%) followed. VE1 immunostaining results were positive in all 15 cases with BRAF V600E mutation (sensitivity 100%), and negative in 4 cases of BRAF non-V600E mutation. However, VE1 immunostaining was negative in all 22 patients with BRAF wild-type. Conclusion: VE1 immunostaining had a good correlation with BRAF V600E mutation status.
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참고문헌 (29)
참고문헌 신청
김상엽 / 2016 / Cutaneous Melanoma in Asians / 전남의대학술지 52(3):185~193
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Wilson MA / 2012 / Molecular testing in melanoma / Cancer J 18:117~123
National Cancer Institute / 0000 / FDA approval for Dabrafenib [Internet]
Davies H / 2002 / Mutations of the BRAF gene in human cancer / Nature 417:949~954
National Cancer Institute / 0000 / FDA approval for vemurafenib [Internet]
Wilson MA / 2012 / Molecular testing in melanoma / Cancer J 18:117~123
National Cancer Institute / 0000 / FDA approval for Dabrafenib [Internet]
Davies H / 2002 / Mutations of the BRAF gene in human cancer / Nature 417:949~954
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