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자료유형
학술저널
저자정보
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제63권 제3호
발행연도
2020.1
수록면
215 - 224 (10page)

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Metabolic syndrome (MetS) is a group of risk factors that causes cardiovascular and diabetic morbidity and mortality,which is diagnosed by central obesity, dyslipidemia, hyperglycemia, and hypertension. Increasing epidemiological dataand experimental results indicate that the presence of MetS increases the incidence of common malignancies andrelated mortality. Epidemiological studies have previously reported an association of endometrial cancer occurrencewith MetS. Aromatization of androstenedione to estrogen, insulin resistance, and diabetes can cause increased levelsof free estrogen, and the detrimental effect of elevated estrogen as a carcinogen is well studied in endometrialcancer. Medications used to manage MetS such as metformin and statins are suggested to reduce endometrial cancerrisk and improve survival. Some large population-based epidemiological studies have suggested that the MetS isrelated to an increased risk of cervical carcinoma. MetS may contribute to viral-host interactions, which lead topersistent human papilloma virus (HPV) infection, although limited epidemiological data are available. Specific effectsof obesity and diabetes on the occurrence of ovarian cancer have been suggested. However, the direct correlationbetween MetS and ovarian cancer is still lacking. Previous retrospective studies reported that the use of metformin,statins, and beta-blockers could be associated with cancer prevention or better prognosis. Proper diagnosis andmanagement of the MetS should be a part of the strategies undertaken to prevent and treat gynecologic cancer. Sofar, only limited data is available on this subject, and further clinical and fundamental research is required to furtherclarify the effect of these therapies on gynecologic cancer treatment.

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