지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 140 - 144 (5page)
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Background and Purpose The high prevalence of antiphospholipid antibodies (aPL) and antinuclear antibodies (ANA) in patients with epilepsy may be associated with either the disease itself or the antiepileptic treatment. The purpose of this prospective study was to determine the prevalence of aPL and ANA in children with idiopathic epilepsy before and during treatment with antiepileptic drugs. Methods aPL, including both anticardiolipin and anti-β2-glycoprotein I antibodies, and ANA statuses were determined in 40 healthy children, 30 children treated with sodium valproate (VPA) monotherapy, and 20 children treated with carbamazepine (CBZ) monotherapy before and at 6, 12, and 24 months after treatment initiation. Results Fifteen children (50%) in the VPA-treated group and 7 (35%) in the CBZ-treated group showed positivity for aPL before treatment initiation, compared with only 4 of the 40 controls. Nine children (30%) in the VPA-treated group and 4 (20%) in the CBZ-treated group showed positivity for ANA before treatment initiation, compared with only 2 of the 40 controls. The subgroup analysis found nonsignificant associations at the different time points regarding the positivity of all of the autoantibodies. Only patients treated with VPA had a significantly decreased risk of aPL positivity after 6 months of treatment. Conclusions The increased prevalence of autoantibodies in children with idiopathic epilepsy is strongly associated with the disease itself.
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참고문헌 (15)
참고문헌 신청
Rumsey DG / 2017 / Diagnosis and treatment of antiphospholipid syndrome in childhood : a review / Blood Cells Mol Dis 67:34~40
Agmon-Levin N / 2014 / International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies / Ann Rheum Dis 73:17~23
Constantin T / 2009 / Prevalence of antiphospholipid and antinuclear antibodies in children with epilepsy / Med Sci Monit 15:CR164~CR169
Dlott JS / 2012 / Drug-induced lupus anticoagulants and antiphospholipid antibodies / Curr Rheumatol Rep 14:71~78
Brey RL / 2011 / Antiphospholipid antibodies and the brain : a consensus report / Lupus 20:153~157
Agmon-Levin N / 2014 / International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies / Ann Rheum Dis 73:17~23
Constantin T / 2009 / Prevalence of antiphospholipid and antinuclear antibodies in children with epilepsy / Med Sci Monit 15:CR164~CR169
Dlott JS / 2012 / Drug-induced lupus anticoagulants and antiphospholipid antibodies / Curr Rheumatol Rep 14:71~78
Brey RL / 2011 / Antiphospholipid antibodies and the brain : a consensus report / Lupus 20:153~157
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