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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제4호
- 발행연도
- 2019.1
- 수록면
- 495 - 502 (8page)
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초록· 키워드
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Objective: The present study aimed to observe potential benefit of aripiprazole augmentation in the treatment of major depressive disorder with mixed specifier (MDDM) in naturalistic treatment setting. Methods: Data were collected from MDDM patients using a retrospective chart review for 8 weeks (week −8 and week 0) in routine practice. All patients were on current antidepressants upon starting of aripiprazole. Patients were treated without restriction of doses of aripiprazole. The primary endpoint was the mean change of Montgomery−Åsberg Depression Rating Scale (MADRS) total scores along with various secondary endpoint measures. Results: In total 38 patients were analyzed. The changes of MADRS, Clinical Global Impression (CGI)-severity, Young Mania Rating Scale, Sheehan Disability Scale, and CGI-clinical benefit total scores from baseline to the endpoint were −7.1, −0.8, −4.9, −4.1, and −3.6, respectively (all p ＜ 0.0001). At the endpoint, the responder and remitter rates by MADRS score criteria were approximately 32% and 21%, respectively. Conclusion: The present findings have clearly shown the effectiveness and tolerability of aripiprazole augmentation for MDDM patients in routine practice. The present study warrants subsequent, adequately-powered, well-controlled studies for generalizability near future.
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참고문헌 (44)
참고문헌 신청
Rush AJ / 2007 / STAR*D : what have we learned / Am J Psychiatry 164:201~204
우영섭 / 2017 / Dose Trends of Aripiprazole from 2004 to 2014 in Psychiatric Inpatients in Korea / Clinical Psychopharmacology and Neuroscience 15(2):177~180
Changsu Han / 2018 / A Pharmacogenomic-based Antidepressant Treatment for Patients with Major Depressive Disorder: Results from an 8-week, Randomized, Single-blinded Clinical Trial / Clinical Psychopharmacology and Neuroscience 16(4):469~480
Dold M / 2017 / Clinical characteristics and treatment outcomes of patients with major depressive disorder and comorbid anxiety disorders-results from a European multicenter study / J Psychiatr Res 91:1~13
McIntyre RS / 2015 / The prevalence and illness characteristics of DSM-5-defined"mixed feature specifier"in adults with major depressive disorder and bipolar disorder : results from the International Mood Disorders Collaborative Project / J Affect Disord 172:259~264
우영섭 / 2017 / Dose Trends of Aripiprazole from 2004 to 2014 in Psychiatric Inpatients in Korea / Clinical Psychopharmacology and Neuroscience 15(2):177~180
Changsu Han / 2018 / A Pharmacogenomic-based Antidepressant Treatment for Patients with Major Depressive Disorder: Results from an 8-week, Randomized, Single-blinded Clinical Trial / Clinical Psychopharmacology and Neuroscience 16(4):469~480
Dold M / 2017 / Clinical characteristics and treatment outcomes of patients with major depressive disorder and comorbid anxiety disorders-results from a European multicenter study / J Psychiatr Res 91:1~13
McIntyre RS / 2015 / The prevalence and illness characteristics of DSM-5-defined"mixed feature specifier"in adults with major depressive disorder and bipolar disorder : results from the International Mood Disorders Collaborative Project / J Affect Disord 172:259~264
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