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This study was investigated the synergistic antibacterial effects from the combination of sulfamethazine (SMZ) and tiamulin (SMT) against Salmonella Typhimurium (S. Typhimurium) and Actinobacillus pleuropneumoniae (A. pleuropneumoniae) isolated from pigs. Minimum inhibitory concentrations (MICs) and fractional inhibitory concentration (FIC) index were determined for 10 bacteria from 13 swine farms in Gyeongsangnam province by the National Committee for Clinical Laboratory Standards broth microdilution procedure. Antimicrobial agents tested included SMZ, tiamulin and SMT. Against S. Typhimurium and A. pleuropneumoniae, the MIC ranges of SMZ, tiamulin and SMT were 125-500, 15.625-62.5 and 15.625-62.5 μg/mL, respectively. In addition, the FIC index ranges of SMT against S. Typhimurium and A. pleuropneumoniae were 0.19-0.38 and 0.19-0.62, respectively. In conclusion, SMT has a high antibacterial activity against S. Typhimurium and A. pleuropneumoniae, then the combination may be applied for the treatment of swine diseases caused by S. Typhimurium and A. pleuropneumoniae.
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참고문헌 (29)
참고문헌 신청
Bonapace CR / 2002 / Determination of antibiotic effect in an in vitro pharmacodynamic model:comparison with an established animal model of infection / Antimicrob Agents Chemother 46:3571~3579
Araque M / 2009 / Nontyphoid Salmonella gastroenteritis in pediatric patients from urban areas in the city of Merida, Venezuela / J Infect Dev Ctries 3:28~34
Boucher HW / 2009 / Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America / Clin Infect Dis 48:1~12
Buyck JM / 2015 / Activities of antibiotic combinations against resistant strains of Pseudomonas aeruginosa in a model of infected THP-1 monocytes / Antimicrob Agents Chemother 59:258~268
Choi MJ / 2012 / The in vitro antibacterial activity of enrofloxacin-trimethoprim combination against five bacterial species / Pak Vet J 32:363~366
Araque M / 2009 / Nontyphoid Salmonella gastroenteritis in pediatric patients from urban areas in the city of Merida, Venezuela / J Infect Dev Ctries 3:28~34
Boucher HW / 2009 / Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America / Clin Infect Dis 48:1~12
Buyck JM / 2015 / Activities of antibiotic combinations against resistant strains of Pseudomonas aeruginosa in a model of infected THP-1 monocytes / Antimicrob Agents Chemother 59:258~268
Choi MJ / 2012 / The in vitro antibacterial activity of enrofloxacin-trimethoprim combination against five bacterial species / Pak Vet J 32:363~366
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