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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 678 - 686 (9page)
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The purpose of this study was to examine the physiochemical characteristics of hot water extract of Caragana sinica roots and verified its protective effect on MIA-induced osteoarthritis in rats. The contents of total polyphenol and total flavonoid used in this experiment were 0.40 mg/g and 0.22 mg/g respectively. We found that the weight of all experiment groups which ingested Caragana sinica extract for three weeks evenly increased in rats with MIA-induced osteoarthritis without toxicity in the liver or kidney. In the histopathological test through the Mankin score, the extent of damage of knee joint tissue in the experiment groups to which Caragana sinica extract was administered in 5 mL/kg or 10 mL/kg was significantly lower than that of the negative control groups statistically(p<0.05). As for the grade of osteoarthritis, the extent of tissue damage of the experiment groups to which Caragana sinica extract was administered in 5 mL/kg or 10 mL/kg was lower than that of the negative control groups as well.
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참고문헌 (41)
참고문헌 신청
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Belia S / 1998 / Sodium nitroprusside, a NO donor, modifies Ca2+ transport and mechanical properties in frog skeletal muscle / J Muscle Res Cell Motil 19:865~876
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DiPiro JT / 2005 / Pharmacotherapy: A Pathophysiologic Approach / McGraw-Hill :1860~1862
Folin O / 1912 / On phosphotungstic-phosphomolybdic compounds as color reagents / J Bio Chem 12:239~249
Belia S / 1998 / Sodium nitroprusside, a NO donor, modifies Ca2+ transport and mechanical properties in frog skeletal muscle / J Muscle Res Cell Motil 19:865~876
Dai J / 2010 / Plant phenolics : Extraction, analysis and their antioxidant and anticancer properties / Molecules 15:7313~7352
DiPiro JT / 2005 / Pharmacotherapy: A Pathophysiologic Approach / McGraw-Hill :1860~1862
Folin O / 1912 / On phosphotungstic-phosphomolybdic compounds as color reagents / J Bio Chem 12:239~249
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