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서희원; 이하나; 전현웅; 변하영; 정재호; 이승환

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자료유형: 학술저널

저자정보: 서희원 이하나 전현웅 변하영 정재호 이승환

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제63권 제6호

발행연도: 2020.1

수록면: 252 - 258 (7page)

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연구주제

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연구배경

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연구방법

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연구결과

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Background and Objectives We aimed to compare the treatment outcomes of primary intratympanicsteroid (ITS) and the salvage ITS protocol. Subjects and Method We assessed 440 patients with unilateral idiopathic sudden sensorineuralhearing loss (ISSNHL) from January 2016 to December 2019. Of the 440 patients, 37patients received ITS only as a primary treatment while other patients received systemic steroid;of those remaining patients, 276 received systemic steroid as well as ITS as a salvagetreatment. We performed a 1:2 propensity score matching analysis for both groups using parameterssuch as the initial hearing level, presence of vertigo, onset of treatment, age, sex, hypertensionand diabetes. The rate of hearing recovery was determinied by comparing thematching propensity score between the primary ITS and the control group according to theAmerican Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guideline andSiegel’s criteria. Results Of the 440 ISSNHL patients, 28.9% received systemic steroid only and 62.6% ofpatients were managed with systemic steroid plus salvage ITS. Thirty-seven patients (8.4%)were managed with ITS only. While 36.8% of patients completely recovered, 35.0% did notrecover their hearing according to AAO-HNS guideline. The propensity score matchingshowed that the initial hearing level, age and onset of treatment were not significantly differentbetween the primary ITS and control group. Regarding the treatment outcome, completerecovery rate for the primary ITS group and control group were 29.7% and 33.8%, respectively. Although the recovery rate of the salvage ITS protocol group was higher than that of theprimary ITS group, statistical significance was not identified. Conclusion Treatment strategies of primary ITS and salvage ITS protocol did not significantlyaffect the clinical outcomes of ISSNHL differently.

참고문헌 (22)

참고문헌 신청

Rauch SD / 2008 / Clinical practice. Idiopathic sudden sensorineural hearing loss / N Engl J Med 359(8):833~840

이현수 / 2014 / A Clinical Analysis of Sudden Sensorineural Hearing Loss Cases / Journal of Audiology & Otology 18(2):69~75

Chung JH / 2016 / Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss / Laryngoscope 126(8):1918~1922

Wilson WR / 1980 / The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study / Arch Otolaryngol 106(12):772~776

Hobson CE / 2016 / Primary treatment of idiopathic sudden sensorineural hearing loss with intratympanic dexamethasone / Curr Opin Otolaryngol Head Neck Surg 24(5):407~412

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