지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 52 - 58 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: SMAD4 is a member of the SMAD family and acts as a central mediator of transforming growth factor beta signaling. Little is known about SMAD4 expression and its prognostic significance in breast cancer. We evaluated the clinicopathological and prognostic significance of SMAD4 expression in breast cancer. Methods: Two hundred and fifty-five patients with invasive ductal carcinoma of the breast from 2000 to 2008 were retrospectively analyzed. We investigated SMAD4 expression using a tissue microarray-based immunohistochemical assay and evaluated the association between SMAD4 and prognosis of breast cancer. Results: High SMAD4 expression was positively associated with early stage (p=0.009), estrogen receptor positivity (p=0.026), and human epidermal growth factor receptor 2 negativity (p=0.001). A significant difference in overall survival (OS) was associated with high SMAD4 expression in patients with T1 stage tumors (hazard ratio: 0.459, p=0.024). Conclusion: High SMAD4 expression was correlated with several favorable prognostic factors and was associated with favorable OS in T1 stage breast cancer. SMAD4 in breast cancer has potential prognostic significance, and further investigations and understanding about SMAD4 expression are needed.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Siegel RL / 2017 / Colorectal cancer statistics, 2017 / CA Cancer J Clin 67:177~193
Guo F / 2018 / Trends in breast cancer mortality by stage at diagnosis among young women in the United States / Cancer 124:3500~3509
Fayanju OM / 2018 / Molecular genomic testing for breast cancer: utility for surgeons / Ann Surg Oncol 25:512~519
Heldin CH / 1997 / TGF-beta signalling from cell membrane to nucleus through SMAD proteins / Nature 390:465~471
Miyaki M / 1999 / Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis / Oncogene 18:3098~3103
Guo F / 2018 / Trends in breast cancer mortality by stage at diagnosis among young women in the United States / Cancer 124:3500~3509
Fayanju OM / 2018 / Molecular genomic testing for breast cancer: utility for surgeons / Ann Surg Oncol 25:512~519
Heldin CH / 1997 / TGF-beta signalling from cell membrane to nucleus through SMAD proteins / Nature 390:465~471
Miyaki M / 1999 / Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis / Oncogene 18:3098~3103
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clinicopathological Characterization and Prognostic Implication of SMAD4 Expression in Colorectal Carcinoma
Journal of Pathology and Translational Medicine
2019 .01
-
Clinicopathological signifi cance of SMAD4 Expression in Breast Cancer
대한외과학회 학술대회 초록집
2019 .10
-
Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/ SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
Journal of Breast Cancer
2018 .01
-
Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/ SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
Journal of Breast Cancer
2018 .01
-
A study on the mechanism of resistance to non-small cell lung cancer therapeutic application using mouse orthotopic model
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation
대한암예방학회지
2018 .01
-
Smad3 deficiency accelerates tongue wound healing via epithelial cell-extracellular matrix interactions
Oral Biology Research
2022 .12
-
Smad1 Expression in Follicular Lymphoma
Journal of Pathology and Translational Medicine
2015 .01
-
The Smad4/PTEN Expression Pattern Predicts Clinical Outcomes in Colorectal Adenocarcinoma
Journal of Pathology and Translational Medicine
2018 .01
-
Signaling web of SMADs and STAT3 in the development of arthritogenic Th17
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Dendritic cell specific targeting of Smad2 enhances anti-tumor immunity
한국실험동물학회 학술발표대회 논문집
2019 .07
-
The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1
Tuberculosis and Respiratory Diseases
2019 .01
-
Pokemon Inhibits Transforming Growth Factor β-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1
Journal of Breast Cancer
2019 .01
-
음양곽(淫羊藿) 열수 추출물의 Smad 신호 억제를 통한 간성상세포의 활성 조절
대한한의학방제학회지
2018 .01
-
Pine bark extract (Pycnogenol®) suppresses cigarette smoke-induced fibrotic response via transforming growth factor-β1/Smad family member 2/3 signaling
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Aspirin-Triggered Resolvin D1 Inhibits TGF-β1-Induced EndMT through Increasing the Expression of Smad7 and Is Closely Related to Oxidative Stress
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Maximum standard uptake value as a clinical biomarker for detecting loss of SMAD4 expression and early systemic tumor recurrence in resected left-sided pancreatic cancer
한국간담췌외과학회 학술대회지
2016 .04
-
Copper oxide nanoparticles induce a fibrotic response via TGF-β1/Smad3 signaling in human airway epithelial cells
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Copper oxide nanoparticles induce a fibrotic response via TGF-β1/Smad3 signaling in human airway epithelial cells
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Predictive Factors of Pathologic N2/N3 Disease in Clinical or Pathologic N1 ER+/HER2- Breast Cancer
대한외과학회 학술대회 초록집
2023 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0