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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 163 - 163 (1page)
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By contrast with the numerous genetic mechanisms of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in EGFR-mutated non-small cell lung cancers (NSCLC), the few mechanisms of resistance have been reported. Transforming growth factor (TGF)-β is the pivotal cytokine to regulate the progression and metastasis of cancers. Canonical TGF-β signaling pathway is mediated through TGF-β-specific receptor-regulated SMADs: SMAD2 and SMAD3 and the common SMAD: SMAD4. Despite of the crucial roles of TGF-β signaling in NSCLC physiological features, little is known about the mechanisms SMAD-mediated TGF-β signaling regulates resistance in NSCLC. We examined lung adenocarcinoma cell lines: HCC827 harboring EGFRE746_A750del and mouse Ex3LL ... 전체 초록 보기
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