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- 학술대회자료
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- 대한약학회 대한약학회 학술대회 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
- 발행연도
- 2003.1
- 수록면
- 1,712 - 1,712 (1page)
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Over the past few years, a variety of macrocyclic salicylate natural products have been isolated from both terrestrial and marine sources based on their ability to induce a particular phenotype in mammalian cells. Extracts of the myxobacterium Chondromyces showed high cytotoxicity against cultivated mammalian cells and bio-guided fractionation revealed the cytotoxicity was due to one main metabolite identified as the novel macrolide apicularen A. Beginning to understand the molecular basis for these distinct activities will require structure-function correlation studies and the development of synthetic chemistry in this area. (omitted)
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