지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Two isoforms of cyclooxygenase (COX) have been identified - COX-1, which is constitlitively expressed in most tissues, and the inducible form, COX-2, of which expression is induced by inflammatory signals and mitogens. It has been considered that the beneficial effects of NSAIDs are due to the inhibition of COX-2 activity and the side effects are from the inhibition of COX-1 activity. Therefore, it is essential to develop selective COX-2 inhibitor for developing new GI-tolerable NSAIDS. To discover new leads for developing selective COX-2 inhibitors, three-hundred extracts of natural products were primarily screened with the system of prostaglandin accumulation in LPS-stimulated mouse peritoneal macrophages. To identify whether these inhibitory activities of crude extracts on the accumulation of Prostaglandins were derived from direct action against COX-2, the effects of selected extracts on exogenous arachidonic acid-derived production of prostaglandins by LPS-stimulated macrophages were determined. Among them, 5 methanol extracts of natural products, such as Zingiberis Rhizoma, Alpinae Officinarum Rhizoma, Caryophilli Flos, Scutellariae Radix, Dalbergia ordorifera. inhibited more than 70% of the prostaglandin production in LPS-stimulated mouse peritoneal macrophages at a con-centration of 1${\mu}$g/ml.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cyclooxygenase 억제제 검색을 통한 항염증제 개발 연구
대한화장품학회지
1994 .01
-
COX-2 억제제의 구조-활성
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2001 .01
-
LPS로 활성화된 U937 세포에서 Prostaglandin E2 (PGE2) 생성 및 Cyclooxygenase-2 (COX-2) 활성 억제에 대한 한약제의 평가
동의생리병리학회지
2006 .04
-
천연물로부터 사이클로옥시게나제-2 저해제 검색
약학회지
1998 .01
-
EFFECTS OF ISOTHIAZOLE AND ISOXAZOLE DERIVATIVES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS
대한약학회 학술대회
2002 .01
-
Cyclooxygenase-2 저해제로서의 benzothiazine 유도체 합성과 항염작용 평가
약학회지
2000 .01
-
새로운 COX-2 억제제
대한내과학회지
2016 .01
-
인간 자궁내막에서 Cyclooxygenase-1과 -2의 주기적 발현 양상
대한불임학회잡지
1998 .01
-
LPS로 활성화된 U937세포에서 Prostaglandin $E_2\;(PGE_2)$ 생성 및 Cyclooxygenase-2 (COX-2) 활성 억제에 대한 한약제의 평가
동의생리병리학회지
2006 .01
-
Synthesis and Biological Activity of Annulated Pyrazoles as Selective COX-2 Inhibitors. I.
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1999 .01
-
Inhibition of cyclooxygenase-2 expression by Caffeoyl-4-dihydrocaffeoyl quinic acid in macrophages
대한약학회 학술대회
2003 .01
-
Suppressive effects on the expression of cyclooxygenase-2 and inducible nitric oxide synthase by a natural sesquiterpenoid in lipopolysaccharide-stimulated mouse macrophage cells
한국응용약물학회 추계학술발표논문집
2003 .01
-
항정신병 약물이 Cyclooxygenase-2 유전자 발현과 Prostaglandin E₂ 농도에 미치는 영향
생물치료정신의학
2001 .12
-
인체 호흡기 상피세포에서 IL-1β에 의한 Cyclooxygenase-2의 발현
대한이비인후-두경부외과학회지
2002 .01
-
Eugenol suppresses inducible cyclooxygenase-2(COX-2) expressionin lipopolysaccharide-stimulated mouse macrophage cells.
한국응용약물학회 추계학술발표논문집
2001 .01
-
Inhibitory effect of Panax notoginseng and berberine on LPS-induced iNOS, COX-2 and prostaglandin E2
대한동의병리학회 학술대회논문집
2006 .09
-
Inhibitory Effect of Panax notoginseng and Berberine on LPS-induced iNOS, COX-2 and Prostaglandin E2
동의생리병리학회지
2006 .10
-
Inhibitory effect of Panax notoginseng and emodin on LPS-induced iNOS, COX-2 and prostaglandin E2
동의생리병리학회지
2006 .06
-
퇴행성 뇌질환 치료제 Tacrine 유도체의 프로스타글란딘 생합성 억제효과
약학회지
2005 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0