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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 363 - 374 (12page)
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초록· 키워드
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Dried fruits of Schizandra chinensis Baillon, Fructus Schisandrae, have been widely used for many years to prevent and treat various diseases in Asian countries including Korea and Russia. It has recently been reported that extracts of Fructus Schisandrae are effective for controlling muscle and skeletal diseases. In this study, we investigated the efficacy of ethanol extract of Fructus Schisandrae (EEFS) on apoptosis and inflammatory response in gastrocnemius muscle of dexamethasone-induced catabolic muscle atrophy mice as part of natural substance discovery and functional analysis for improving muscle function. According to the results of this study, EEFS supplementation attenuated body weight gains and suppressed calf thickness loss in dexamethasone-induced muscle atrophic mice. Gastrocnemius muscle immunohistochemistry showed that expression of caspase-3 and poly(ADP-ribose) polymerase, which are representative apoptotic markers, was markedly increased in dexamethasone control mice; however, their expression was effectively reduced in the EEFS-fed mice. EEFS supplementation also prevented dexamethasone-induced increases in immunoreactivity of muscle fibers for myostatin, an important negative regulator of skeletal muscle mass. In addition, EEFS significantly normalized the increased numbers of nitrotyrosine, 4-hydroxynonenal and inducible nitric oxide synthase-positive muscle fibers compared to that found in dexamethasone control mice. These results suggest that EEFS protects dexamethasone-induced muscular atrophy by decreasing apoptosis and inflammatory responses, and EEFS is more likely to be developed as a muscle strengthening agent.
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참고문헌 (54)
참고문헌 신청
Glass DJ. / 2003 / Molecular mechanisms modulating muscle mass / Trends Mol Med 9:344~350
Jackman RW / 2004 / The molecular basis of skeletal muscle atrophy / Am J Physiol Cell Physiol 287:C834~C843
Kanda F / 1999 / Preventive effects of insulin like growth factor-I on steroid-induced muscle atrophy / Muscle Nerve 22:213~217
Benveniste O / 2005 / MuSK antibody positive myasthenia gravis plasma modifies MURF-1expression in C2C12 cultures and mouse muscle in vivo / J Neuroimmunol 170:41~48
Jones A / 2010 / Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy / Endocrinology 151:3706~3719
Jackman RW / 2004 / The molecular basis of skeletal muscle atrophy / Am J Physiol Cell Physiol 287:C834~C843
Kanda F / 1999 / Preventive effects of insulin like growth factor-I on steroid-induced muscle atrophy / Muscle Nerve 22:213~217
Benveniste O / 2005 / MuSK antibody positive myasthenia gravis plasma modifies MURF-1expression in C2C12 cultures and mouse muscle in vivo / J Neuroimmunol 170:41~48
Jones A / 2010 / Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy / Endocrinology 151:3706~3719
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